Methylprednisolone acetate

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Methylprednisolone acetate
Methylprednisolone acetate.svg
Clinical data
Trade namesDepo-Medrol, Depo-Medrate, Depo-Medrone, others
Other namesDepot methylprednisolone acetate; Methylprednisolone 21-acetate; 6α-Methylprednisolone 21-acetate; NSC-48985
Routes of
Intramuscular injection
Drug classCorticosteroid; Glucocorticoid
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.000.157 Edit this at Wikidata
Chemical and physical data
Molar mass416.514 g·mol−1
3D model (JSmol)

Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and veterinary medicine.[1][2][3][4][5][6][7] It has been formulated as an aqueous suspension for intramuscular, intra-articular, soft tissue, and intralesional injection alone and in combination with lidocaine, a local anesthetic.[1][4][5] Methylprednisolone acetate was previously suspended with polyethylene glycol but is no longer formulated with this excipient due to concerns about possible toxicity.[6][8] Depot methylprednisolone acetate is a depot injection and is absorbed slowly with a duration of weeks to months with a single intramuscular injection.[5]

See also[edit]


  1. ^ a b "Depo-Medrol- methylprednisolone acetate injection, suspension". DailyMed. 18 January 2019. Retrieved 19 February 2020.
  2. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–. ISBN 978-1-4757-2085-3.
  3. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–. ISBN 978-3-88763-075-1.
  4. ^ a b Muller NF, Dessing RP, eds. (19 June 1998). European Drug Index: European Drug Registrations (Fourth ed.). CRC Press. pp. 337–. ISBN 978-3-7692-2114-5.
  5. ^ a b c Plumb DC (21 February 2018). Plumb's Veterinary Drug Handbook: Pocket. John Wiley & Sons. pp. 1088–1091. ISBN 978-1-119-34649-4.
  6. ^ a b Lennard TA, Vivian DG, Walkowski, Singla AK (11 June 2011). Pain Procedures in Clinical Practice E-Book. Elsevier Health Sciences. pp. 8–. ISBN 978-1-4377-3774-5.
  7. ^ Scott DW, Miller Jr WH (1 December 2010). Equine Dermatology - E-Book. Elsevier Health Sciences. pp. 122–. ISBN 978-1-4377-0921-6.
  8. ^ Canale ST, Beaty JH (29 October 2012). Campbell's Operative Orthopaedics E-Book. Elsevier Health Sciences. pp. 1906–. ISBN 978-0-323-08718-6.