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DepoDur CII, previously known as DepoMorphine, is a morphine sulfate extended-release liposome injection (see Depot injection), product of Pacira Pharmaceuticals (formerly SkyePharma PLC). It was approved by the U.S. Food and Drug Administration (FDA) in 2004 for use as a post-surgical pain reliever. In Europe, it was approved by the Medicines and Healthcare Products Regulatory Agency in 2006.

It is a one-time injection (during or shortly after surgery) that maintains a therapeutically effective level of morphine in the patient's bloodstream for 48 hours.

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