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Depolarization or depolarizer may refer to:
- Depolarization, a decrease in the absolute value of a cell's membrane potential
- Depolarizer, a substance used to depolarize an electrochemical cell
- Depolarization ratio, the intensity ratio between the parallel component and the perpendicular component of Raman scattered light
- Depolarizer (optics), a device for randomizing the polarization of light
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