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Dequalinium chloride
Dequalinium chloride.png
IUPAC name
1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium) decyl]-2-methyl-4-quinolin-1-iumamine dichloride
3D model (JSmol)
ECHA InfoCard 100.007.575
MeSH Dequalinium
Molar mass 456.678 g·mol−1
D08AH01 (WHO) G01AC05 (WHO), R02AA02 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Dequalinium is a quaternary ammonium cation and bolaamphiphile commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications:

Dequadin an antiseptic and disinfectant. It is a topical bacteriostat. It is used in wound dressings and mouth infections and may also have antifungal action. It may cause skin ulceration.

Fluomizin, vaginal tablets containing 10 mg dequalinium chloride, are used for treating vaginal bacterial conditions (i.e. Bacterial Vaginosis and aerobic vaginitis).

The dequalinium dication is symmetrical, containing two quaternary quinolinium units linked by an N-decylene chain.


Dequalinium salts may be used to treat malaria.[1] As dequalinium chloride, it can be used in lozenges to cure sore throats however while this is effective in vitro, it is not effective in cases of streptococci infections [2]


  1. ^ "US Patent 4946849". United States Patents and Trademarks Office (USPTO). 10 October 1989. Retrieved 2008-03-15.
  2. ^ Krämer W. (1977). "[Treatment of tonsilitis with dequalinium chloride]". Fortschr. Med. (in German). 95 (16): 1108–10. PMID 856702.

Further reading[edit]

  • Gamboa-Vujicic, Gisela; Emma, Dennis A.; Liao, Shu Y.; Fuchtner, Carlos; Manetta, Alberto (1993). "Toxicity of the mitochondrial poison dequalinium chloride in a murine model system". Journal of Pharmaceutical Sciences. 82 (3): 231–5. doi:10.1002/jps.2600820302. PMID 8450414.

External links[edit]