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A dermatoxin (from derma, the Greek word for skin) is a toxic chemical that damages skin, mucous membranes, or both, often leading to tissue necrosis. Dermatoxins can be drugs, natural chemicals, or synthetic chemicals.

The severity of the effects of a dermatoxic agent is strongly dependent on the dose, route of exposure, rate at which it spreads, and the health of the afflicted individual.

Examples of dermatoxic substances[edit]

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