Derrubone

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Derrubone
Derrubone.svg
Names
IUPAC name
3-(1,3-Benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)chromen-4-one
Other names
5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone
Identifiers
3D model (Jmol)
ChemSpider
Properties
C21H18O6
Molar mass 366.37 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.[1] Recent research indicates that it acts as an inhibitor of Hsp90 to its function as a chaperone protein.[2]

References[edit]

  1. ^ East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta(roxb.) benth.". J. Chem. Soc. C. 3: 365–74. doi:10.1039/J39690000365. 
  2. ^ Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS (December 2007). "Derrubone, an inhibitor of the Hsp90 protein folding machinery". J. Nat. Prod. 70 (12): 2014–8. doi:10.1021/np070190s. PMID 18020309.