Desmethylsertraline

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Desmethylsertraline
Desmethylsertraline skeletal.svg
Systematic (IUPAC) name
(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine
Clinical data
Legal status
  • uncontrolled
Pharmacokinetic data
Biological half-life 66 hours
Excretion urine
Identifiers
CAS Registry Number 87857-41-8
ATC code None
PubChem CID: 114743
ChemSpider 102729
Chemical data
Formula C16H15Cl2N
Molecular mass 292.20 g/mol

Desmethylsertraline (DMS) is an active metabolite of the antidepressant drug sertraline. Like sertraline, desmethylsertraline acts as a monoamine reuptake inhibitor, and may be responsible for some of its parent's therapeutic benefits. However, DMS is significantly less potent relative to sertraline as a serotonin reuptake inhibitor (Ki = 76 nM vs. 3 nM, respectively), but conversely, is more balanced as a monoamine reuptake inhibitor (5-HT (Ki) = 76 nM; NE (Ki) = 420 nM; DA (Ki) = 440 nM), which has the effective result of DMS contrarily behaving as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with about 5.5-fold preference for inhibiting serotonin reuptake relative to catecholamine reuptake.[1]

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