Desmoglein-3
Template:PBB Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene.[1][2]
Function
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.[2]
Interactions
Desmoglein 3 has been shown to interact with PKP3.[3]
See also
- Desmoglein
- List of target antigens in pemphigus
- List of conditions caused by problems with junctional proteins
References
- ^ Arnemann J, Spurr NK, Buxton RS (Jul 1992). "The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18". Hum Genet. 89 (3): 347–50. doi:10.1007/bf00220557. PMID 1601426.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)".
- ^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (April 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
- Amagai M, Klaus-Kovtun V, Stanley JR (1992). "Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion". Cell. 67 (5): 869–77. doi:10.1016/0092-8674(91)90360-B. PMID 1720352.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Roh JY, Stanley JR (1995). "Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment". J. Invest. Dermatol. 104 (5): 720–4. doi:10.1111/1523-1747.ep12606963. PMID 7738346.
- Wang Y, Amagai M, Minoshima S; et al. (1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12". Genomics. 20 (3): 492–5. doi:10.1006/geno.1994.1207. PMID 8034325.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Schäfer S, Koch PJ, Franke WW (1994). "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins". Exp. Cell Res. 211 (2): 391–9. doi:10.1006/excr.1994.1103. PMID 8143788.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Kárpáti S, Amagai M, Prussick R; et al. (1993). "Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes". J. Cell Biol. 122 (2): 409–15. doi:10.1083/jcb.122.2.409. PMC 2119642. PMID 8320263.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Silos SA, Tamai K, Li K; et al. (1996). "Cloning of the gene for human pemphigus vulgaris antigen (desmoglein 3), a desmosomal cadherin. Characterization of the promoter region and identification of a keratinocyte-specific cis-element". J. Biol. Chem. 271 (29): 17504–11. doi:10.1074/jbc.271.29.17504. PMID 8663392.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Marsden MD, Collins JE, Greenwood MD; et al. (1997). "Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2)". Gene. 186 (2): 237–47. doi:10.1016/S0378-1119(96)00715-9. PMID 9074502.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Adams MJ, Reichel MB, King IA; et al. (1998). "Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens". Biochem. J. 329. ( Pt 1): 165–74. PMC 1219028. PMID 9405290.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Shirakata Y, Amagai M, Hanakawa Y; et al. (1998). "Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1". J. Invest. Dermatol. 110 (1): 76–8. doi:10.1046/j.1523-1747.1998.00085.x. PMID 9424092.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Amagai M, Nishikawa T, Nousari HC; et al. (1998). "Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice". J. Clin. Invest. 102 (4): 775–82. doi:10.1172/JCI3647. PMC 508940. PMID 9710446.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Ishikawa H, Li K, Tamai K; et al. (2001). "Cloning of the mouse desmoglein 3 gene (Dsg3): interspecies conservation within the cadherin superfamily". Exp. Dermatol. 9 (4): 229–39. doi:10.1034/j.1600-0625.2000.009004229.x. PMID 10949543.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Czerwenka KF, Manavi M, Hosmann J; et al. (2001). "Comparative analysis of two-dimensional protein patterns in malignant and normal human breast tissue". Cancer Detect. Prev. 25 (3): 268–79. PMID 11425269.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Weiske J, Schöneberg T, Schröder W; et al. (2001). "The fate of desmosomal proteins in apoptotic cells". J. Biol. Chem. 276 (44): 41175–81. doi:10.1074/jbc.M105769200. PMID 11500511.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Andl CD, Stanley JR (2001). "Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes". J. Invest. Dermatol. 117 (5): 1068–74. doi:10.1046/j.0022-202x.2001.01528.x. PMID 11710914.
- Merritt AJ, Berika MY, Zhai W; et al. (2002). "Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation". Mol. Cell. Biol. 22 (16): 5846–58. doi:10.1128/MCB.22.16.5846-5858.2002. PMC 133994. PMID 12138195.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Hanakawa Y, Amagai M, Shirakata Y; et al. (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231–6. doi:10.1046/j.1523-1747.2002.19648.x. PMID 12485422.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Veldman C, Stauber A, Wassmuth R; et al. (2003). "Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles". J. Immunol. 170 (1): 635–42. doi:10.4049/jimmunol.170.1.635. PMID 12496453.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Posthaus H, Dubois CM, Müller E (2003). "Novel insights into cadherin processing by subtilisin-like convertases". FEBS Lett. 536 (1–3): 203–8. doi:10.1016/S0014-5793(02)03897-8. PMID 12586364.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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