Tom Baker played the Fourth Doctor from 1974 to 1981. Although Big Finish Productions has been producing audio dramas with all the other living, Classic Series Doctors since 1999, Tom Baker had declined to participate. Baker finally reprised the role in a series of audio dramas for the BBC in 2009, starting with Hornets' Nest. Destination Nerva is the first in a series of audio dramas produced by Big Finish Productions.
Having wrapped up their adventure with Jago and Litefoot in Victorian London, the Doctor and Leela are alerted to an interstellar distress signal emanating from an English manor house, in the nearby year of 1895. From there, they chase an alien spaceship a millennium into the future, to the newly constructed Space Dock Nerva, orbiting Jupiter.
The Fourth Doctor was previously on-board Nerva in the 1975 television story The Ark in Space. That was several thousand years into the future, when "Space Station Nerva" was converted to house the cryogenically frozen survivors of the human race, as they orbited an inhospitable Earth. The Doctor returned to "Nerva Beacon", thousands of years earlier, in Revenge of the Cybermen, when it orbited a moon of Jupiter. In Destination: Nerva, "Space Dock Nerva" has only just been built.