Dettelbach was first named as a settlement in 741 AD; the town was founded in 1484 AD. Dettelbach has a nearly complete medieval city wall including towers, and two remaining town gates. Dettelbach's most prominent architectural features are cobble-stoned streets with picturesque rows of half-timbered houses, and historic buildings dating as far back as the Renaissance, or even late-Gothic era.
Dettelbach is famous for its wine, available from a number of local wineries. One major tourist attraction is the annual wine fest in the heart of downtown. The festival takes place every year from the Catholic Feast of Corpus Christi to the Sunday following the holiday. A local specialty are "Muskatzinen", flavorful pastries spiced with nutmeg, made after a secret recipe.