According to the 19th-century historian A.J. van der Aa, this hamlet was the location of the first Reformed preaching in the area in 1566, by Cornelis van Diest. In the siege of 's-Hertogenbosch in 1629, Deuteren was the location of the headquarters of colonel Pinsen. The hamlet suffered a lot of damage in the year 1757 by high water and ice shelves.
Formerly, the hamlet was divided into two parts: Groot-Deuteren (the current hamlet) and Klein-Deuteren, about 1 km to the northeast. The latter part had shrunk to only one house in the middle of the 19th century; nowadays, a suburb of 's-Hertogenbosch covers the area of Klein-Deuteren.
- Abraham Jacob van der Aa, "Aardrijkskundig woordenboek der Nederlanden", vol. 3 (C/D), 1841, p. 268.
- J. Kuyper, Gemeente Atlas van Nederland, 1865-1870, "Cromvoirt". Map of Cromvoirt in 1868, showing Groot- and Klein-Deuteren.