Diisopropyltryptamine

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Diisopropyltryptamine
DiPT.svg
DiPT-3d-sticks.png
Clinical data
SynonymsN,N-Diisopropyltryptamine, DiPT
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEBI
Chemical and physical data
FormulaC16H24N2
Molar mass244.379 g/mol
3D model (JSmol)
  (verify)

Diisopropyltryptamine (/ˌdˌsˌprpɪlˈtrɪptəmn/; also known as N,N-diisopropyltryptamine or DiPT) is a psychedelic hallucinogenic drug of the tryptamine family that has a unique effect. While the majority of hallucinogens affect the visual sense, DiPT is primarily aural.[1]

Hallucinogenic properties[edit]

DiPT's effects are primarily aural. At lower doses, Alexander Shulgin reported effects similar to a flanging or a phase shift. At medium and higher dosages, the effect of DiPT is typically a radical shift downward in perceived pitch. This shift tends to be nonlinear, in that the shift downwards varies in relation to the initial pitch. This can produce bizarre sounds and render music disharmonious.[1] There has been an experiment involving subjects with perfect pitch, the goal of which was to determine whether the pitch difference is truly distortive or linear, the results of which indicated that there is no clear relationship between perceived pitch and actual pitch.[1] Aside from these, the most prevalent non-auditory effect is inner ear pressure (which has been painful in some instances, for example when combined with MDMA).[1]

Chemistry[edit]

DiPT is a derivative of tryptamine formed by substituting isopropyl groups for the two hydrogen atoms attached to the non-aromatic nitrogen atom in the tryptamine molecule.

Pharmacodynamics[edit]

Binding sites Binding affinity (Ki, µM)[2]
5-HT1A 0.538
5-HT2A 1.2
5-HT2C 6.5
D1 >25
D2 >25
D3 >25
α1A >12
α2A 3.6
TAAR1 >15
H1 0.92
SERT 0.18
DAT 4.1
NET 8.9

Legal status[edit]

United Kingdom[edit]

As is the case with many PiHKAL and TiHKAL drugs, it is Class A in the UK, making it illegal to possess or use.

United States[edit]

DiPT is not scheduled at the federal level in the United States,[3] but it could be considered an analog of 5-MeO-DiPT, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act. Some of the people arrested in Operation Web Tryp were selling DiPT.

Florida[edit]

"DiPT (N,N-Diisopropyltryptamine)" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[4]

See also[edit]

References[edit]

  1. ^ a b c d Shulgin, Alexander (1997). TiHKAL: Tryptamines I Have Known and Loved. Berkeley, CA USA: Transform Press. pp. 403–406. ISBN 0-9630096-9-9.
  2. ^ Rickli A.; Moning O.D.; Hoener M.C.; Liechti M.E. (2016). "Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens". European Neuropsychopharmacology. 26 (8): 1327–37. doi:10.1016/j.euroneuro.2016.05.001. PMID 27216487.
  3. ^ 21 CFR — SCHEDULES OF CONTROLLED SUBSTANCES §1308.11 Schedule I.
  4. ^ Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL

External links[edit]