Diamine N-acetyltransferase

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diamine N-acetyltransferase
Spermidine N-acetyltransferase dodekamer, Vibrio cholerae
EC number2.3.1.57
CAS number54596-36-0
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a diamine N-acetyltransferase (EC is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an alkane-alpha,omega-diamine CoA + an N-acetyldiamine

Thus, the two substrates of this enzyme are acetyl-CoA and alkane-alpha,omega-diamine, whereas its two products are CoA and N-acetyldiamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase. Other names in common use include spermidine acetyltransferase, putrescine acetyltransferase, putrescine (diamine)-acetylating enzyme, diamine acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine N1-acetyltransferase, acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, putrescine acetylase, and putrescine N-acetyltransferase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies[edit]

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 2B3U, 2B3V, 2B4B, 2B4D, 2B58, 2B5G, 2BEI, 2F5I, 2FXF, 2G3T, 2JEV, and 2Q4V.


  • Ragione FD, Pegg AE (1982). "Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver". Biochemistry. 21 (24): 6152&ndash, 8. doi:10.1021/bi00267a020. PMID 7150547.