Diamine oxidase, also known as histaminase, is an enzyme ( EC 220.127.116.11) involved in the metabolism, oxidation, and inactivation of histamine in animals. Highest content is observed in the digestive tract and placenta. It is also secreted by eosinophils.  
References [ edit ]
^ PDB: 3HI7
^ McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM (2009). "Structure and inhibition of human diamine oxidase". Biochemistry. 48 (41): 9810–22. doi: 10.1021/bi9014192. PMC 2791411 . PMID 19764817.
^ Zeiger RS, Colten HR (1977). "Histaminase release from human eosinophils". Journal of Immunology. 118 (2): 540–3. PMID 402420.
^ Agúndez JA, Ayuso P, Cornejo-García JA, Blanca M, Torres MJ, Doña I, Salas M, Blanca-López N, Canto G, Rondon C, Campo P, Laguna JJ, Fernández J, Martínez C, García-Martín E (2012). "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs". PLoS ONE. 7 (11): e47571. doi: 10.1371/journal.pone.0047571. PMC 3495953 . PMID 23152756.
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