Diamine oxidase

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Diamine oxidase
Crystal Structure of Human Diamine Oxidase.png
Ribbon representation of human diamine oxidase[1][2] (rendered with PyMOL)
Identifiers
EC number 1.4.3.22
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Diamine oxidase, also known as histaminase, is an enzyme (EC 1.4.3.22) involved in the metabolism, oxidation, and inactivation of histamine in animals. Highest content is observed in the digestive tract and placenta. It is also secreted by eosinophils.[3][4]

References[edit]

  1. ^ PDB: 3HI7
  2. ^ McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM (2009). "Structure and inhibition of human diamine oxidase". Biochemistry 48 (41): 9810–22. doi:10.1021/bi9014192. PMC 2791411. PMID 19764817. 
  3. ^ Zeiger RS, Colten HR (1977). "Histaminase release from human eosinophils". Journal of Immunology 118 (2): 540–3. PMID 402420. 
  4. ^ Agúndez JA, Ayuso P, Cornejo-García JA, Blanca M, Torres MJ, Doña I, Salas M, Blanca-López N, Canto G, Rondon C, Campo P, Laguna JJ, Fernández J, Martínez C, García-Martín E (2012). "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs". PLoS ONE 7 (11): e47571. doi:10.1371/journal.pone.0047571. PMC 3495953. PMID 23152756. 

External links[edit]