Diamine oxidase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Diamine oxidase
Crystal Structure of Human Diamine Oxidase.png
Ribbon representation of human diamine oxidase[1][2] (rendered with PyMOL)
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Diamine oxidase, also known as histaminase, is an enzyme (EC involved in the metabolism, oxidation, and inactivation of histamine in animals. Highest content is observed in the digestive tract and placenta. It is also secreted by eosinophils.[3][4]


  1. ^ PDB: 3HI7
  2. ^ McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM (2009). "Structure and inhibition of human diamine oxidase". Biochemistry. 48 (41): 9810–22. doi:10.1021/bi9014192. PMC 2791411free to read. PMID 19764817. 
  3. ^ Zeiger RS, Colten HR (1977). "Histaminase release from human eosinophils". Journal of Immunology. 118 (2): 540–3. PMID 402420. 
  4. ^ Agúndez JA, Ayuso P, Cornejo-García JA, Blanca M, Torres MJ, Doña I, Salas M, Blanca-López N, Canto G, Rondon C, Campo P, Laguna JJ, Fernández J, Martínez C, García-Martín E (2012). "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs". PLoS ONE. 7 (11): e47571. doi:10.1371/journal.pone.0047571. PMC 3495953free to read. PMID 23152756. 

External links[edit]