Dicyclohexylurea

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Dicyclohexylurea
Dicyclohexylurea.png
Names
IUPAC name
1,3-dicyclohexylurea
Other names
DCU
Identifiers
3D model (JSmol)
ChemSpider
Properties
C13H24N2O
Molar mass 224.35 g·mol−1
Melting point 230 to 233 °C (446 to 451 °F; 503 to 506 K)
Hazards
Safety data sheet External MSDS
S-phrases (outdated) S24/25
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Dicyclohexylurea is an organic compound, specifically, a urea. It is the byproduct of the reaction of dicyclohexylcarbodiimide with amines or alcohols. It may be prepared by the reaction of cyclohexylamine and S,S-dimethyl dithiocarbonate.[1] 1,3-Dicyclohexyl urea (DCU) is a potent soluble epoxide hydrolase (sEH) inhibitor. It has been shown to lower systemic blood pressure by 22 ± 4 mmHg in SHR [2]

References[edit]

  1. ^ Man-kit Leung; Jun-Liang Lai; King-Hang Lau; Hsiao-hua Yu; Hsiang-Ju Hsiao (1996). "S,S-Dimethyl Dithiocarbonate: A Convenient Reagent for the Synthesis of Symmetrical and Unsymmetrical Ureas". The Journal of Organic Chemistry. 61 (12): 4175–4179. PMID 11667305. doi:10.1021/jo9522825. 
  2. ^ Sarbani Ghosh, Po-Chang Chiang, Jan L. Wahlstrom, Hideji Fujiwara, Jon G. Selbo andSteven L. Roberds (2008). "Oral Delivery of 1,3-Dicyclohexylurea Nanosuspension Enhances Exposure and Lowers Blood Pressure in Hypertensive Rats". Basic & Clinical Pharmacology & Toxicology. 102 (5): 453–458. doi:10.1111/j.1742-7843.2008.00213.x.