Didier Stainier

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Didier Stainier
Didier Stainier.jpg
Born1963 (age 55–56)
Liège, Belgium
ResidenceGermany
NationalityBelgian/American
Alma mater
Awards
Scientific career
Fields
Institutions
Doctoral advisorWalter Gilbert
Other academic advisorsMark Fishman

Didier Stainier (born 1963) is a Belgian/American developmental geneticist who is currently a director at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany.[1][2]

Scientific career[edit]

Didier Stainier studied biology in Wales (United World College of the Atlantic), Belgium (University of Liège) and the USA (Brandeis University) where he got a BA in 1984. He has a PhD in biochemistry and biophysics from Harvard University (1990). During his PhD work, he investigated axon guidance and target recognition in the developing mouse with Walter Gilbert. Subsequently, he initiated the studies on zebrafish cardiac development as a Helen Hay Whitney postdoctoral fellow with Mark Fishman at the Massachusetts General Hospital (Boston).

Scientific interests[edit]

Together with the many students and postdocs in his laboratory, Stainier helped pioneer the use of the zebrafish model to study a wide range of questions pertaining to vertebrate organ development and function,[3] and has published extensively.[4][5][6] His forward genetic analyses of heart development revealed the unexpected role of several signaling pathways including sphingosine 1-phosphate signaling[7] and the discovery of the long-elusive sphingosine 1-phosphate transporter.[8][9] Additional genetic screens led to the elucidation of transcriptional networks regulating endoderm formation[10] and endothelial cell specification[11] as well as extracellular signals regulating liver induction.[12] He pushed the frontiers of in vivo microscopy[13] to reveal new insights into cardiac valve formation[14] and cardiac trabeculation, and used cellular approaches to gain a detailed understanding of these processes. Stainier developed and used single-cell analyses to provide the first in vivo demonstration of the hemangioblast,[15] a formerly hypothetical cell that gives rise to both endothelial and blood cells, as well as the discovery of a new mode of blood vessel formation.[16] His studies on gut looping morphogenesis revealed the importance of tissue-level physical forces in shaping organs,[17] and his studies on gut lumen formation revealed the importance of fluid flow in this process.[18] He developed a number of cell ablation models that allowed him and others to gain new insights into the process of organ regeneration, with potential implications for novel disease therapies.[19] Most recently, he has also made significant contributions to the understanding of genetic compensation.[20]

Selected awards and honors[edit]

References[edit]

  1. ^ "Board of Directors, MPI for Heart and Lung Research". mpi-hlr.de. Retrieved 4 February 2018.
  2. ^ "Bio on the Max Planck Society's website". mpg.de. Retrieved 4 February 2018.
  3. ^ "Transparent eggs of the zebra fish let researchers see how DNA directs embryonic development". sfgate.com. Retrieved 4 February 2018.
  4. ^ Search Results for author Stainier D on PubMed.
  5. ^ "Scopus - author information". scopus.com. Retrieved 4 February 2018.
  6. ^ "Google Scholars - author information". scholar.google.com. Retrieved 4 February 2018.
  7. ^ Kupperman, Erik; An, Songzhu; Osborne, Nick; Waldron, Steven; Stainier, Didier Y. R (2000). "A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development". Nature. 406 (6792): 192–5. doi:10.1038/35018092. PMID 10910360.
  8. ^ Osborne, Nick; Brand-Arzamendi, Koroboshka; Ober, Elke A; Jin, Suk-Won; Verkade, Heather; Holtzman, Nathalia Glickman; Yelon, Deborah; Stainier, Didier Y.R (2008). "The Spinster Homolog, Two of Hearts, is Required for Sphingosine 1-Phosphate Signaling in Zebrafish". Current Biology. 18 (23): 1882–8. doi:10.1016/j.cub.2008.10.061. PMC 2741689. PMID 19062281.
  9. ^ "A Small Fish Unlocks a Secret of the Heart". sfgate.com. Retrieved 4 February 2018.
  10. ^ Alexander, Jonathan; Stainier, Didier Y.R (1999). "A molecular pathway leading to endoderm formation in zebrafish". Current Biology. 9 (20): 1147–57. doi:10.1016/S0960-9822(00)80016-0. PMID 10531029.
  11. ^ Reischauer, Sven; Stone, Oliver A; Villasenor, Alethia; Chi, Neil; Jin, Suk-Won; Martin, Marcel; Lee, Miler T; Fukuda, Nana; Marass, Michele; Witty, Alec; Fiddes, Ian; Kuo, Taiyi; Chung, Won-Suk; Salek, Sherveen; Lerrigo, Robert; Alsiö, Jessica; Luo, Shujun; Tworus, Dominika; Augustine, Sruthy M; Mucenieks, Sophie; Nystedt, Björn; Giraldez, Antonio J; Schroth, Gary P; Andersson, Olov; Stainier, Didier Y. R (2016). "Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification". Nature. 535 (7611): 294–8. doi:10.1038/nature18614. PMID 27411634.
  12. ^ Ober, Elke A; Verkade, Heather; Field, Holly A; Stainier, Didier Y. R (2006). "Mesodermal Wnt2b signalling positively regulates liver specification". Nature. 442 (7103): 688–91. doi:10.1038/nature04888. PMID 16799568.
  13. ^ Arrenberg, A. B; Stainier, D. Y. R; Baier, H; Huisken, J (2010). "Optogenetic Control of Cardiac Function". Science. 330 (6006): 971–4. doi:10.1126/science.1195929. PMID 21071670.
  14. ^ Walsh, E. C; Stainier, D. Y (2001). "UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish". Science. 293 (5535): 1670–3. doi:10.1126/science.293.5535.1670. PMID 11533493.
  15. ^ Vogeli, Kevin M; Jin, Suk-Won; Martin, Gail R; Stainier, Didier Y. R (2006). "A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula". Nature. 443 (7109): 337–9. doi:10.1038/nature05045. PMID 16988712.
  16. ^ Herbert, S. P; Huisken, J; Kim, T. N; Feldman, M. E; Houseman, B. T; Wang, R. A; Shokat, K. M; Stainier, D. Y. R (2009). "Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation". Science. 326 (5950): 294–8. doi:10.1126/science.1178577. PMC 2865998. PMID 19815777.
  17. ^ Horne-Badovinac, S; Rebagliati, M; Stainier, D. Y (2003). "A Cellular Framework for Gut-Looping Morphogenesis in Zebrafish". Science. 302 (5645): 662–5. doi:10.1126/science.1085397. PMID 14576439.
  18. ^ Bagnat, Michel; Cheung, Isla D; Mostov, Keith E; Stainier, Didier Y. R (2007). "Genetic control of single lumen formation in the zebrafish gut". Nature Cell Biology. 9 (8): 954–60. doi:10.1038/ncb1621. PMID 17632505.
  19. ^ Andersson, Olov; Adams, Bruce A; Yoo, Daniel; Ellis, Gregory C; Gut, Philipp; Anderson, Ryan M; German, Michael S; Stainier, Didier Y.R (2012). "Adenosine Signaling Promotes Regeneration of Pancreatic β Cells In Vivo". Cell Metabolism. 15 (6): 885–94. doi:10.1016/j.cmet.2012.04.018. PMC 3372708. PMID 22608007.
  20. ^ Rossi, Andrea; Kontarakis, Zacharias; Gerri, Claudia; Nolte, Hendrik; Hölper, Soraya; Krüger, Marcus; Stainier, Didier Y. R (2015). "Genetic compensation induced by deleterious mutations but not gene knockdowns". Nature. 524 (7564): 230–3. doi:10.1038/nature14580. PMID 26168398.
  21. ^ "Helen Hay Whitney Foundation Fellow profile". hhwf.org. Retrieved 4 February 2018.
  22. ^ "Packard Foundation Fellow in Science and Engineering". packard.org. Retrieved 4 February 2018.
  23. ^ "Elected Fellow of the American Association for the Advancement of Science". aaas.org. Retrieved 4 February 2018.
  24. ^ "Officier dans l'ordre de Léopold de Belgique, Nomination by Royal Decree published on 18 December 2013 on etaamb.be from the Belgian Official Journal". etaamb.be. Retrieved 4 February 2018.
  25. ^ "Ten Max Planck researchers receive funding boosts worth millions". mpg.de. Retrieved 4 February 2018.
  26. ^ "58 life science researchers elected as new EMBO Members". embo.org. Retrieved 4 February 2018.
  27. ^ "EMBO member profile". people.embo.org. Retrieved 4 February 2018.
  28. ^ "Academia Europaea member profile". ae-info.org. Retrieved 4 February 2018.
  29. ^ "Didier Stainier receives 'Christiane Nüsslein-Volhard Award'". eufishbiomed.kit.edu. Retrieved 4 February 2018.
  30. ^ "Didier Stainier receives 'Christiane Nüsslein-Volhard Award'". mpi-hlr.de. Retrieved 4 February 2018.

Interviews[edit]

Videos[edit]

External links[edit]