Dienestrol diacetate

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Dienestrol diacetate
Dienestrol diacetate.svg
Clinical data
Trade names Faragynol, Gynocyrol
Drug class Nonsteroidal estrogen; Estrogen ester
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C22H22O4
Molar mass 350.41 g·mol−1
3D model (JSmol)

Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1] It is an ester of dienestrol.[1]

Oral potencies of estrogens
Estrogen Type EPD
(mg/14 days)
EPD
(mg/day)
MSD
(mg/14 days)
MSD
(mg/day)
Estradiol (micronized) Bioidentical 60 4.3 14–28 1.0–2.0
Estradiol valerate Bioidentical 60 4.3 14–28 1.0–2.0
Estriol Bioidentical 140–150a 10.0–10.7a 28–84 2.0–6.0
Estriol succinate Bioidentical 140–150a 10.0–10.7a 28–84 2.0–6.0
Conjugated estrogens Natural 60 4.3 8.4–17.5 0.6–1.25
Ethinylestradiol Synthetic 1.0–1.5 0.071–0.11 0.28 0.02
Mestranol Synthetic 1.5–1.8 0.11–0.13 0.35 0.025
Quinestrol Synthetic 2.0–4.0 0.14–0.29 ND ND
Diethylstilbestrol Synthetic 20–30 1.4–2.1 ND ND
Diethylstilbestrol dipropionate Synthetic 15–20 1.1–1.4 ND ND
Dienestrol diacetate Synthetic 40–60 2.9–4.3 ND ND
Footnotes: a = Taken in divided doses three times per day. Abbreviations: EPD = Endometrial proliferation dose. MSD = Menopausal substitution dose. Miscellaneous: Direct link to table. Sources:[2][3][4][5]

References[edit]

  1. ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 390. ISBN 978-1-4757-2085-3. 
  2. ^ Lauritzen C (September 1990). "Clinical use of oestrogens and progestogens". Maturitas. 12 (3): 199–214. doi:10.1016/0378-5122(90)90004-P. PMID 2215269. 
  3. ^ Alfred S. Wolf; H.P.G. Schneider (12 March 2013). Östrogene in Diagnostik und Therapie. Springer-Verlag. pp. 78–. ISBN 978-3-642-75101-1. 
  4. ^ Gunther Göretzlehner; Christian Lauritzen; Thomas Römer; Winfried Rossmanith (1 January 2012). Praktische Hormontherapie in der Gynäkologie. Walter de Gruyter. pp. 44–. ISBN 978-3-11-024568-4. 
  5. ^ Karl Knörr; Fritz K. Beller; Christian Lauritzen (17 April 2013). Lehrbuch der Gynäkologie. Springer-Verlag. pp. 212–213. ISBN 978-3-662-00942-0.