Dihydrodeoxycorticosterone

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dihydrodeoxycorticosterone
Dihydrodeoxycorticosterone.svg
Names
IUPAC name
(5α)-21-Hydroxypregnane-3,20-dione
Other names
5α-Dihydro-11-deoxycorticosterone
Identifiers
298-36-2
ChemSpider 4953958
Jmol 3D model Interactive image
PubChem 6451493
Properties
C21H32O3
Molar mass 332.48 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid.[1] It is synthesized from the adrenal hormone deoxycorticosterone (DOC) by the enzyme 5α-reductase type I.[1] DHDOC is an agonist of the progesterone receptor, as well as a positive allosteric modulator of the GABAA receptor, and is known to have anticonvulsant effects.[1][2]

See also[edit]

References[edit]

  1. ^ a b c Reddy DS, Rogawski MA (May 2002). "Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility". J. Neurosci. 22 (9): 3795–805. PMID 11978855. 
  2. ^ Edwards HE, Vimal S, Burnham WM (December 2005). "The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses". Epilepsia. 46 (12): 1888–97. doi:10.1111/j.1528-1167.2005.00295.x. PMID 16393154.