|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / EGO|
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase. Other names in common use include dihydroflavanol 4-reductase (DFR), dihydromyricetin reductase, NADPH-dihydromyricetin reductase, and dihydroquercetin reductase. This enzyme participates in flavonoid biosynthesis.
Researchers in Japan have genetically manipulated roses by using RNA interference to knock out endogenous DFR, adding a gene DFR from an iris, and adding a gene for the blue pigment, delphinidin, in an effort to create a blue rose, which is being sold worldwide.
Dihydroflavonol 4-reductase is an enzyme part of the lignin biosynthesis pathway. In Arabidopsis thaliana, the enzyme uses sinapaldehyde or coniferyl aldehyde or coumaraldehyde and NADPH to produce sinapyl alcohol or coniferyl alcohol or coumaryl alcohol respectively and NADP+.
- Nakajima J, Tanaka Y, Yamazaki M, Saito K (July 2001). "Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis". J. Biol. Chem. 276 (28): 25797–803. doi:10.1074/jbc.M100744200. PMID 11316805.
- "Leucodelphinidin biosynthesis". MetaCyc. SRI International.
- Les cibles d’amélioration pour la qualité des raisins: L’exemple des flavonoïdes, Nancy Terrier (French)
- The isolation, molecular characterization and expression of dihydroflavonol 4-reductase cDNA in the orchid, Bromheadia finlaysoniana. Chye-Fong Liew, Chiang-Shiong Loh, Chong-Jin Goh and Saw-Hoon Lim, Plant Science, Volume 135, Issue 2, 10 July 1998, Pages 161–169, doi:10.1016/S0168-9452(98)00071-5
- Katsumoto Y et al (2007) Engineering of the Rose Flavonoid Biosynthetic Pathway Successfully Generated Blue-Hued Flowers Accumulating Delphinidin Plant Cell Physiol. 48(11): 1589–1600 
- Phys.Org website. April 4, 2005 Plant gene replacement results in the world's only blue rose
- "Dihydroflavonol 4-reductase". Arabidopsis Reactome.
- Heller W, Forkmann G, Britsch L, Grisebach H (1985). "Enzymatic reduction of (+)-dihydroflavonols to flavan-3,4-cis- diols with flower extracts from Matthiola incana and its role in anthocyanin biosynthesis". Planta. 165 (2): 284–287. doi:10.1007/BF00395052.
- Stafford HA; Lester HH (1985). "Flavan-3-ol biosynthesis the conversion of (+)- dihydromyricetin to its flavan-3,4-diol (leucodelphinidin) and to (+)-gallocatechin by reductases extracted from tissue-cultures of Ginkgo biloba and Pseudotsuga-menziesii". Plant Physiol. 78 (4): 791–794. doi:10.1104/pp.78.4.791.
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