Dihydropyridine

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Dihydropyridine
Skeletal formula of dihydropyridine
Ball-and-stick model of the dihydropyridine molecule
Names
Systematic IUPAC name
1,4-Dihydropyridine[1]
Identifiers
3337-17-5 YesY
ChemSpider 94619 YesY
Jmol-3D images Image
MeSH 1,4-dihydropyridine
PubChem 104822
Properties
C
5
H
7
N
Molar mass 81.1158 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 YesY verify (what isYesY/N?)
Infobox references

Dihydropyridine is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) which have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Class members[edit]

The L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries): These are derivatives of dihydropyridine.

Name Image Brand name
Amlodipine
Amlodipine.svg
Norvasc, Istin, Normodipine, Tenox, Cordi Cor
Aranidipine
Aranidipine.svg
Sapresta (サプレスタ)
Azelnidipine
Azelnidipine structure.svg
CalBlock (カルブロック)
Barnidipine
Barnidipine structure.svg
Vasexten, Libradin, Cyress, HypoCa
Benidipine
Benidipine structure.svg
Coniel
Cilnidipine
Cilnidipine.svg
Atelec (アテレック), Cilacar, Cinalong, Siscard
Clevidipine
Clevidipine structure.svg
Cleviprex
Cronidipine
Cronidipine.svg
Darodipine
Darodipine structure.svg
Dexniguldipine
Dexniguldipine.svg
Efonidipine
Efonidipine structure.svg
Landel (ランデル)
Elgodipine
Elgodipine.svg
Elnadipine
Elnadipine.svg
Felodipine
Felodipine structure.svg
Renedil, Plendil
Flordipine
Flordipine.svg
Furnidipine
Furnidipine.svg
Iganidipine
Iganidipine.svg
Isradipine
Isradipine.svg
DynaCirc CR
Lacidipine
Lacidipine structure.svg
Lacipil, Motens, Sakure
Lemildipine
Lemildipine.svg
Lercanidipine
Lercanidipine.svg
Zanidip, Zanidip-Recordati
Levamlodipine
Levamlodipine.svg
EsCordi Cor
Levniguldipine
Levniguldipine.svg
Manidipine
Manidipine.svg
Manyper, Caslot, Madipine
Nicardipine
Nicardipine.svg
Cardene, Cardene SR
Nifedipine
Nifedipine.svg
Adalat, Nifedical, Procardia, Corinfar, Cordaflex
Niguldipine
Niguldipine structure.svg
Niludipine
Niludipine.svg
Nilvadipine
Nilvadipine structure.svg
Nivadil
Nimodipine
Nimodipine structure.svg
Nimotop
Nisoldipine
Nisoldipine structure.svg
Sular, Baymycard, Syscor
Nitrendipine
Nitrendipine.svg
Baypress, Cardif, Nitrepin, Baylotensin
Olradipine
Olradipine.svg
Oxodipine
Oxodipine structure.svg
Palonidipine
Palonidipine.svg
Pranidipine
Pranidipine structure.svg
Acalas
Ryodipine
Ryodipine structure.svg
Sagandipine
Sagandipine.svg
Sornidipine
Sornidipine.svg
Teludipine
Teludipine.svg
Tiamdipine
Tiamdipine.svg
Trombodipine
Trombodipine.svg
Vatanidipine
Vatanidipine.svg

See also[edit]

References[edit]

  1. ^ "1,4-dihydropyridine - Compound Summary". Pubchem Compound. USA: National Center for Biotechnology Information. 27 March 2005. Identification and Related Records. Retrieved 1 November 2011. 

External links[edit]