Dihydropyrimidine dehydrogenase

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dihydropyrimidine dehydrogenase
Symbol DPYD
Entrez 1806
HUGO 3012
OMIM 274270
RefSeq NM_000110
Other data
EC number
Locus Chr. 1 p22
Dihydropyrimidine dehydrogenase (NADP(+))
EC number
CAS number 9029-01-0
Alt. names Dihydrothymine dehydrogenase
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism.[citation needed] It catalyzes the reduction of uracil and thymine.[1] It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur.[2]

See also[edit]


  1. ^ Chung T, Na J, Kim YI, Chang DY, Kim YI, Kim H, Moon HE, Kang KW, Lee DS, Chung JK, Kim SS, Suh-Kim H, Paek SH, Youn H (2016). "Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas". Theranostics. 6 (10): 1477–90. PMC 4955049Freely accessible. PMID 27446484. doi:10.7150/thno.14158. 
  2. ^ Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M (December 2013). "Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing". Clinical Pharmacology and Therapeutics. 94 (6): 640–5. PMC 3831181Freely accessible. PMID 23988873. doi:10.1038/clpt.2013.172.