Dihydrostreptomycin

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Dihydrostreptomycin
Dihydrostreptomycin.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.004.445
Chemical and physical data
Formula C21H41N7O12
Molar mass 583.59 g/mol
3D model (JSmol)
  (verify)

Dihydrostreptomycin is a derivative of streptomycin that has a bactericidal property.[1] It's a semisynthetic aminoglycoside antibiotic used in the treatment of tuberculosis.[2]

It acts by irreversibly binding the S12 protein in the bacterial 30S ribosomal subunit, after being actively transported across the cell membrane, which interferes with the initiation complex between the mRNA and the bacterial ribosome. This leads to the synthesis of defective non-functional proteins, which results in the bacterial cell's death.[1]

It causes ototoxicity,[3] which is why it is no longer used in humans.

See also[edit]

References[edit]

  1. ^ a b "Dihydrostreptomycin (Code C61724) - NCI Thesaurus". Retrieved July 7, 2016. 
  2. ^ "Dihydrostreptomycin Sulfate - MeSH - NCBI". Retrieved July 7, 2016. 
  3. ^ Harrison, Wiley H. (1954). "Ototoxicity of dihydrostreptomycin.". Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School. 28 (3): 271–3. PMC 3803976Freely accessible. PMID 13186082. 

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