|Systematic (IUPAC) name|
2-[(1S,2R,3R,4S,5R,6R)-5-(Diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)- 4,5-dihydroxy-6-(hydroxymethyl)-3-methylaminooxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)- 5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine
|AHFS/Drugs.com||International Drug Names|
|ATC code||S01AA15 (WHO) QA07AA90 (WHO) QJ01GA90 (WHO) QJ51GA90 (WHO)|
|Molar mass||583.59 g/mol|
It acts by irreversibly binding the S12 protein in the bacterial 30S ribosomal subunit, after being actively transported across the cell membrane, which interferes with the initiation complex between the mRNA and the bacterial ribosome. This leads to the synthesis of defective non-functional proteins, which results in the bacterial cell's death.
- "Dihydrostreptomycin (Code C61724) - NCI Thesaurus". Retrieved July 7, 2016.
- "Dihydrostreptomycin Sulfate - MeSH - NCBI". Retrieved July 7, 2016.
- Harrison, Wiley H. (1954). "Ototoxicity of dihydrostreptomycin.". Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School. 28 (3): 271–3. PMC . PMID 13186082.
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