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Molar mass583.59 g/mol g·mol−1
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Dihydrostreptomycin is a bioactive molecule of 2,4(or 5)-diaminocyclohexanol group that inhibits small ribosomal subunit.[1] Dihydrostreptomycin is a derivative of streptomycin that has a bactericidal properties.[2] It is a semisynthetic aminoglycoside antibiotic used in the treatment of tuberculosis.[3]

It acts by irreversibly binding the S12 protein in the bacterial 30S ribosomal subunit, after being actively transported across the cell membrane, which interferes with the initiation complex between the mRNA and the bacterial ribosome. This leads to the synthesis of defective non-functional proteins, which results in the bacterial cell's death.[2]

It causes ototoxicity,[4] which is why it is no longer used in humans.

See also[edit]


  1. ^ Forouzesh, Abed; Samadi Foroushani, Sadegh; Forouzesh, Fatemeh; Zand, Eskandar (2019). "Reliable target prediction of bioactive molecules based on chemical similarity without employing statistical methods". Frontiers in Pharmacology. 10: 835. doi:10.3389/fphar.2019.00835. PMC 6676798. PMID 31404334.
  2. ^ a b "Dihydrostreptomycin (Code C61724) - NCI Thesaurus". Retrieved July 7, 2016.
  3. ^ "Dihydrostreptomycin Sulfate - MeSH - NCBI". Retrieved July 7, 2016.
  4. ^ Harrison, Wiley H. (1954). "Ototoxicity of dihydrostreptomycin". Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School. 28 (3): 271–3. PMC 3803976. PMID 13186082.

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