In enzymology, a dihydrouracil dehydrogenase (NAD+) (EC 188.8.131.52) is an enzyme that catalyzes the chemical reaction
- 5,6-dihydrouracil + NAD+ uracil + NADH + H+
Thus, the two substrates of this enzyme are 5,6-dihydrouracil and NAD+, whereas its 3 products are uracil, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6-dihydrouracil:NAD+ oxidoreductase. Other names in common use include dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, pyrimidine reductase, thymine reductase, uracil reductase, and dihydrouracil dehydrogenase (NAD+). This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coa biosynthesis.
- CAMPBELL LL Jr (1957). "Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase". J. Biol. Chem. 227 (2): 693–700. PMID 13462991.