Dimethylallyltranstransferase

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FDPS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFDPS, FPPS, FPS, POROK9, farnesyl diphosphate synthase
External IDsOMIM: 134629 MGI: 104888 HomoloGene: 1519 GeneCards: FDPS
EC number2.5.1.1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FDPS
Genomic location for FDPS
Band1q22Start155,308,748 bp[1]
End155,320,666 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135821
NM_001135822
NM_001242824
NM_001242825
NM_002004

NM_001253751
NM_134469

RefSeq (protein)

NP_001240680
NP_608219

Location (UCSC)Chr 1: 155.31 – 155.32 MbChr 3: 89.09 – 89.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Dimethylallyltranstransferase
2f8z.jpg
Identifiers
EC number2.5.1.1
CAS number9032-79-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Identifiers
SymbolFDPS
NCBI gene2224
HGNC3631
OMIM134629
RefSeqNM_002004
UniProtP14324
Other data
EC number2.5.1.1
LocusChr. 1 q22

Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).[5][6]

Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160752 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059743 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG (1976). "Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare". Phytochemistry. 15: 91–100. doi:10.1016/s0031-9422(00)89061-5.
  6. ^ Sagami H, Ogura K, Seto S, Kurokawa T (November 1978). "A new prenyltransferase from Micrococcus lysodeikticus". Biochemical and Biophysical Research Communications. 85 (2): 572–8. doi:10.1016/0006-291X(78)91201-9. PMID 736921.

External links[edit]