Dimorphic fungus

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Candida albicans growing as yeast cells and filamentous (hypha) cells

Dimorphic fungi are fungi that can exist in the form of both mold[1] and yeast. This is usually brought about by change in temperature and the fungi are also described as thermally dimorphic fungi.[2] An example is Penicillium marneffei,[3] a human pathogen that grows as a mold at room temperature, and as a yeast at human body temperature.

Ecology of dimorphic fungi[edit]

Several species of dimorphic fungi are important pathogens of humans and other animals, including Coccidioides immitis,[4] Paracoccidioides brasiliensis,[4] Candida albicans,[5] Blastomyces dermatitidis, Histoplasma capsulatum, Sporothrix schenckii, and Emmonsia sp.[6] Some diseases caused by the fungi are:

Many other fungi, including the plant pathogen Ustilago maydis[5] and the cheesemaker's fungus Geotrichum candidum also have dimorphic life cycles.


In medical mycology, these memory aids help students remember that among human pathogens, dimorphism largely reflects temperature:


  1. ^ "Fungi". Archived from the original on June 6, 2009. Retrieved 2009-06-06. Cite uses deprecated parameter |deadurl= (help)
  2. ^ Gauthier, GM (May 2017). "Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival". Mediators Inflamm. – via PMID 28626346.
  3. ^ Chandler JM, Treece ER, Trenary HR, et al. (2008). "Protein profiling of the dimorphic, pathogenic fungus, Penicillium marneffei". Proteome Sci. 6 (1): 17. doi:10.1186/1477-5956-6-17. PMC 2478645. PMID 18533041.
  4. ^ a b "Dimorphic Fungi". Retrieved 2007-08-19.
  5. ^ a b Sánchez-martínez, Cristina; Pérez-martín, José (2001). "Dimorphism in fungal pathogens: Candida albicans and Ustilago maydis—similar inputs, different outputs". Current Opinion in Microbiology. 4 (2): 214–221. doi:10.1016/S1369-5274(00)00191-0. PMID 11282479. Archived from the original on 2009-10-23. Cite uses deprecated parameter |dead-url= (help)
  6. ^ Kenyon, Chris; Bonorchis, Kim; Corcoran, Craig; Meintjes, Graeme; Locketz, Michael; Lehloenya, Rannakoe; Vismer, Hester F.; Naicker, Preneshni; Prozesky, Hans; van Wyk, Marelize; Bamford, Colleen; du Plooy, Moira; Imrie, Gail; Dlamini, Sipho; Borman, Andrew M.; Colebunders, Robert; Yansouni, Cedric P.; Mendelson, Marc; Govender, Nelesh P. (2013). "A Dimorphic Fungus Causing Disseminated Infection in South Africa". New England Journal of Medicine. 369 (15): 1416–1424. doi:10.1056/NEJMoa1215460. ISSN 0028-4793. PMID 24106934.