3D model (JSmol)
|Molar mass||734.053 g·mol−1|
|4.6 ± 0.5 x 10−10 M|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Dipalmitoylphosphatidylcholine (DPPtdCho) is a phospholipid (and a lecithin) consisting of two palmitic acids attached of a phosphatidylcholine head-group and is the major constituent of many pulmonary surfactants. It is zwitterionic by virtue of having a negative charge on the phosphate group and a positive charge on the quaternary ammonium group.
It is thought that a lysophosphatidylcholine (lysoPC) acyltransferase may play a critical role in its synthesis. The identity of this acyltransferase has not yet been confirmed. Dipalmitoylphosphatidylcholine is an exception to the rule of thumb that biological phospholipids are synthesized with a saturated fat at the R1 position and an unsaturated fat at the R2 position.
DPPC is routinely used in formulation of some medicines. For instance it is used in formulation of some therapeutical pulmonary surfactants like Survanta and Beraksurf in order to standardize the content of drug. Also is used for liposome formation in order to delivery of drug in the body.
- Smith, Ross; Tanford, Charles (June 1972). "The critical micelle concentration of l-α-dipalmitoylphosphatidylcholine in water and water/methanol solutions". Journal of Molecular Biology. 67 (1): 75–83. doi:10.1016/0022-2836(72)90387-7. PMID 5042465.
- Chen, X; Hyatt, BA; Mucenski, ML; Mason, RJ; Shannon, JM (2006). "Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells". Proc Natl Acad Sci USA. 103 (31): 11724–11729. Bibcode:2006PNAS..10311724C. doi:10.1073/pnas.0604946103. PMC 1544237. PMID 16864775.
- "Surfactant - Medical Countermeasures Database".
- Li, Jing; Wang, Xuling; Zhang, Ting; Wang, Chunling; Huang, Zhenjun; Luo, Xiang; Deng, Yihui (2015). "A review on phospholipids and their main applications in drug delivery systems". Asian Journal of Pharmaceutical Sciences. 10 (2): 81–98. doi:10.1016/j.ajps.2014.09.004.