Dipeptidase 1

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Dipeptidase 1 (renal)
Protein DPEP1 PDB 1itq.png
PDB rendering based on 1itq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DPEP1 ; MBD1; MDP; RDP
External IDs OMIM179780 MGI94917 HomoloGene80192 IUPHAR: 1393 ChEMBL: 1989 GeneCards: DPEP1 Gene
EC number
RNA expression pattern
PBB GE DPEP1 205983 at tn.png
More reference expression data
Species Human Mouse
Entrez 1800 13479
Ensembl ENSG00000015413 ENSMUSG00000019278
UniProt P16444 P31428
RefSeq (mRNA) NM_001128141 NM_007876
RefSeq (protein) NP_001121613 NP_031902
Location (UCSC) Chr 16:
89.68 – 89.7 Mb
Chr 8:
123.19 – 123.2 Mb
PubMed search [1] [2]

Dipeptidase 1 is an enzyme that in humans is encoded by the DPEP1 gene.[1]


DPEP1 (EC is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982). DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990).[supplied by OMIM][1]


Dipeptidase 1 has been shown to interact with KIAA1279.[2]


  1. ^ a b "Entrez Gene: DPEP1 dipeptidase 1 (renal)". 
  2. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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