DPP3

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DPP3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DPP3, DPPIII, dipeptidyl peptidase 3
External IDs MGI: 1922471 HomoloGene: 40210 GeneCards: DPP3
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for DPP3
Genomic location for DPP3
Band 11q13.2 Start 66,480,013 bp[1]
End 66,509,657 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130443
NM_001256670
NM_005700

NM_133803

RefSeq (protein)

NP_001243599
NP_005691
NP_569710

NP_598564

Location (UCSC) Chr 11: 66.48 – 66.51 Mb Chr 11: 4.91 – 4.93 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dipeptidyl-peptidase 3 is an enzyme that in humans is encoded by the DPP3 gene.[5][6]

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000254986 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063904 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Fukasawa KM, Fukasawa K, Harada M (Jun 2000). "Assignment of the dipeptidyl peptidase III gene (DPP3) to human chromosome 11 band q12→q13.1 by in situ hybridization". Cytogenet Cell Genet. 88 (1–2): 99–100. doi:10.1159/000015498. PMID 10773679. 
  6. ^ a b "Entrez Gene: DPP3 dipeptidyl-peptidase 3". 

Further reading[edit]

External links[edit]