|Target disease||Corynebacterium diphtheriae|
|CAS Registry Number|
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Diphtheria vaccine is a vaccine used against Corynebacterium diphtheriae, the agent that causes diphtheria. It use has resulted in a more than 90% decrease in number of cases globally between 1980 and 2000. Three initial doses are recommended after which it is about 95% effective. It is effective for about 10 years at which time a booster dose is needed. Immunization may start at six weeks of age with further doses given every four weeks.
The diphtheria vaccine is very safe. Significant side effects are rare. Pain may occur at the injection site. A bump may form at the site of injection that lasts a few weeks. The vaccine is safe in both pregnancy and among those who have a poor immune function.
Several combination vaccines are used to prevent diphtheria. This includes with tetanus toxoid (known as dT or DT vaccine) and with tetanus and pertussis vaccine known as DPT vaccine. The World Health Organization has recommended it use since 1974. About 84% of the world population is vaccinated. It is given as a intramuscular injection. The vaccine needs to be kept cold but not frozen.
It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.
- "MedlinePlus Medical Encyclopedia: Diphtheria immunization (vaccine)". Retrieved 2009-03-07.[dead link]
- "Diphtheria vaccine" (PDF). Wkly Epidemiol Rec 81 (3): 24–32. Jan 20, 2006. PMID 16671240.
- Atkinson, William (May 2012). Diphtheria Epidemiology and Prevention of Vaccine-Preventable Diseases (12 ed.). Public Health Foundation. pp. 215–230. ISBN 9780983263135.
- "Diphtheria Vaccination". Department of Health and Human Services. Retrieved 8 November 2011.
- "Diphtheria". who.int. 3 September 2014. Retrieved 27 March 2015.
- "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
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