|Ingestion, inhalation, intravenous or intramuscular injection|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||244.382 g·mol−1|
|3D model (JSmol)|
|Melting point||174.5 to 178 °C (346.1 to 352.4 °F)|
N,N-Dipropyltryptamine (DPT) is a psychedelic entheogen belonging to the tryptamine family, first reported in 1973. It is found either as a crystalline hydrochloride salt or as an oily or crystalline base. It has not been found to occur endogenously. It is a close structural homologue of dimethyltryptamine and diethyltryptamine.
Studies on rodents have found that the effectiveness with which a selective 5-HT2A receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor antagonist also imply a 5-HT1A-mediated component to the actions of DPT.
While experiences of apparent entity contact may occasionally occur under the influence of DPT, the perspective is more as an observer or watcher, as contrasted to the more personal and realistic experience reported with DMT.
Negative side effects of human consumption of this drug can include increased heart rate, dizziness, anxiety, confusion, paranoia, seizure and nausea. The use of dipropyltryptamine has caused at least two deaths, both involving seizures.
DPT is used as a religious sacrament by the Temple of the True Inner Light, a New York City offshoot of the Native American Church. The Temple believes DPT and other entheogens are physical manifestations of God.
DPT is a Class A drug in the United Kingdom, making it illegal to possess or distribute .
DPT is not scheduled at the federal level in the United States, but it could be considered an analog of 5-MeO-DiPT, DMT, or DET, in which case purchase, sale, or possession could be prosecuted under the Federal Analogue Act.
DPT is illegal in Sweden as of 26 January 2016.
- Grof S, Soskin RA, Richards WA, Kurland AA (1973). "DPT as an adjunct in psychotherapy of alcoholics". International Pharmacopsychiatry. 8 (1): 104–15. doi:10.1159/000467979. PMID 4150711.
- Fantegrossi WE, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter JC (January 2008). "Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents". Pharmacology, Biochemistry, and Behavior. 88 (3): 358–65. doi:10.1016/j.pbb.2007.09.007. PMC 2322878. PMID 17905422.
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