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Dirlotapide structure.svg
Dirlotapide ball-and-stick model.png
Systematic (IUPAC) name
Clinical data
Trade names Slentrol
AHFS/Drugs.com International Drug Names
Routes of
Legal status
Legal status
Pharmacokinetic data
Protein binding High[1]
Metabolism Hepatic
Biological half-life 5–18 hours (increased with repeated dosing)
Excretion Feces, urine
CAS Number 481658-94-0 YesY
ATCvet code QA08AB91 (WHO)
PubChem CID 9917862
ChemSpider 8093509 YesY
UNII 578H0RMP25 YesY
KEGG D03867 YesY
Chemical data
Formula C40H33F3N4O3
Molar mass 674.71 g/mol

Dirlotapide is a drug used to treat obesity in dogs.[1] It is manufactured by Pfizer and Zoetis and marketed under the brand name Slentrol.

It works as a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor.[2] This blocks the assembly and release of lipoproteins into the bloodstream, thereby reducing fat absorption. It also elicits a satiety signal from lipid-filled cells lining the intestine.


It is supplied as an oral solution. It is not intended for use in humans, cats, birds, rodents, or other animals.

Dirlotapide is used to manage obesity in dogs and helps by reducing appetite. It is used as part of an overall weight control program that also includes proper diet and exercise, under the supervision of a veterinarian. Side effects may include vomiting, diarrhea, lethargy, drooling, or uncoordination. Allergic reaction to the medication may include, facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma.

Regulation and safety[edit]

On January 5, 2007, the U.S. Food and Drug Administration (FDA) approved Slentrol, the first time the FDA has approved a drug for obese dogs.[3][4]

However, concerns have since been raised, since 2010, about adverse effects[5] that might more strongly affect particular breeds.[6]