From Wikipedia, the free encyclopedia
Jump to: navigation, search
Distigmine bromide.svg
Distigmine bromide
Systematic (IUPAC) name
(1-methylpyridin-1-ium-3-yl) N-methyl-N-{6-[methyl-
hexyl}carbamate dibromide
Clinical data
Routes of
oral, i.m.
Pharmacokinetic data
Bioavailability 4.65 % [1]
Biological half-life 65 h [1]
Excretion renal [1]
CAS Number 15876-67-2
ATC code N07AA03 (WHO)
PubChem CID 27522
ChemSpider 25613 YesY
UNII T940307O7B YesY
KEGG D01228
Chemical data
Formula C22H32Br2N4O4
Molar mass 576.322 g/mol

Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.


  1. ^ a b c The Japanese Pharmacopoeia, Edition 14/I: Official Monographs, Yakuji Nippo. Ltd., Tokyo (2001), ISBN 978-4840806725, Page 599.