Distigmine

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Distigmine
Distigmine bromide.svg
Distigmine bromide
Clinical data
Routes of
administration
oral, i.m.
ATC code
Pharmacokinetic data
Bioavailability 4.65% [1]
Elimination half-life 65 h [1]
Excretion renal [1]
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.036.360 Edit this at Wikidata
Chemical and physical data
Formula C22H32Br2N4O4
Molar mass 576.322 g/mol
3D model (JSmol)
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Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.

References[edit]

  1. ^ a b c The Japanese Pharmacopoeia, Edition 14/I: Official Monographs, Yakuji Nippo. Ltd., Tokyo (2001), ISBN 978-4840806725, Page 599.