Diterpenes are a class of chemical compounds composed of two terpene units with the molecular formula C20H32; they may also be thought of as consisting of four isoprene units. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being a primary intermediate. Diterpenes form the basis for biologically important compounds such as retinol, retinal, and phytol. They are known to be antimicrobial and antiinflammatory.
As with most terpenes a huge number of potential structures exists, which may be broadly divided according to the number of rings present.
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Diterpenes are formally defined as being hydrocarbons and thus contain no heteroatoms. Functionalized structures should instead be called diterpeneoids, although in scientific literature the two terms are often used interchangeably. Although a wide range of terpene structures exist few of them are biologically significant, by contrast diterpeneoids possess a rich pharmacology and include important compounds such as retinol and phytol.
- Dodonaea petiolaris yields the diterpene ent-3β-acetoxy- 15,16-epoxylabda-8(17),13(16),14-trien-18-oic acid (C22H28O6) or its enantiomer.
- Salvia divinorum yields Salvinorin A, a psychotropic drug
- Rowinsky, MD, Eric K. (February 1997). "THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS". Annual Review of Medicine 48 (1): 353–374. doi:10.1146/annurev.med.48.1.353.
- The chemistry of Dodonaea spp. VIII. Isolation and crystal structure of a diterpene acid from Dodonaea petiolaris. PR Jefferies, TG Payne, CL Raston and AH White, Australian Journal of Chemistry 34(5) 1001 - 1007
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