Dobrava-Belgrade orthohantavirus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World Orthohantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated from yellow-necked mice (Apodemus flavicollis) found in Dobrava Village[disambiguation needed], Slovenia, Yugoslavia. It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.
Dobrava virus and the variants of Dobrava-Belgrade virus have been found in the yellow-necked mouse (Apodemus flavicollis) virus genotype Dobrava, the Striped field mouse (Apodemus agrarius) virus genotype Kurkino, and Black Sea field mouse (Apodemus ponticus) virus genotype Sochi.
Morbidity and mortality
The fatality rate is 12%, making Dobrava virus the most life-threatening hantavirus disease in Europe. Variant DOBV genotypes have different degrees of pathogenicity.
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