Dock5

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DOCK5
Identifiers
Aliases DOCK5, Dock5, dedicator of cytokinesis 5
External IDs MGI: 2652871 HomoloGene: 57016 GeneCards: DOCK5
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for DOCK5
Genomic location for DOCK5
Band 8p21.2 Start 25,184,723 bp[1]
End 25,418,082 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024940
NM_001322810

NM_177780

RefSeq (protein)

NP_001309739
NP_079216

NP_808448

Location (UCSC) Chr 8: 25.18 – 25.42 Mb Chr 8: 67.75 – 67.93 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dock5 (Dedicator of cytokinesis 5), also known as DOCK5, is a large (~180 kDa) protein involved in intracellular signalling networks.[5] It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins.[6] Dock5 is predicted to activate the small G protein Rac.

Function[edit]

Dock5 shares significant sequence identity with Dock180, the archetypal member of the DOCK family. It is therefore predicted to partake in similar interactions although this has yet to be demonstrated. Indeed, the function and signalling properties of Dock5 are poorly understood thus far. Dock5 has been identified as a crucial signalling protein in osteoclasts,[7] and suppression of Dock5 expression with shRNA has been shown to inhibit survival and differentiation of osteoclast precursor cells.[8] In addition, a mutation in Dock5 has been associated with the rupture of murine lens cataracts.[9] In zebrafish Dock5 has been implicated in myoblast fusion.[10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147459 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044447 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: DOCK5 dedicator of cytokinesis 5". 
  6. ^ Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077. 
  7. ^ Ha BG, Hong JM, Park JY (July 2008). "Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion". Proteomics. 8 (13): 2625–39. doi:10.1002/pmic.200701192. PMID 18600791. 
  8. ^ Brazier H, Stephens S, Ory S (September 2006). "Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts". J. Bone Min. Res. 21 (9): 1387–98. doi:10.1359/jbmr.060613. PMID 16939397. 
  9. ^ Omi N, Kiyokawa E, Matsuda M (May 2008). "Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse". Exp. Eye Res. 86 (5): 828–34. doi:10.1016/j.exer.2008.02.011. PMID 18396277. 
  10. ^ Moore CA, Parkin CA, Bidet Y, Ingham PW (September 2007). "A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion". Development. 134 (17): 3145–53. doi:10.1242/dev.001214. PMID 17670792. 

Further reading[edit]