Dolichyl-phosphate beta-glucosyltransferase

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dolichyl-phosphate beta-glucosyltransferase
EC number2.4.1.117
CAS number71061-42-2
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a dolichyl-phosphate beta-glucosyltransferase (EC is an enzyme that catalyzes the chemical reaction

UDP-glucose + dolichyl phosphate UDP + dolichyl beta-D-glucosyl phosphate

Thus, the two substrates of this enzyme are UDP-glucose and dolichyl phosphate, whereas its two products are UDP and dolichyl beta-D-glucosyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase. Other names in common use include polyprenyl phosphate:UDP-D-glucose glucosyltransferase, UDP-glucose dolichyl-phosphate glucosyltransferase, uridine diphosphoglucose-dolichol glucosyltransferase, UDP-glucose:dolichol phosphate glucosyltransferase, UDP-glucose:dolicholphosphoryl glucosyltransferase, UDP-glucose:dolichyl monophosphate glucosyltransferase, and UDP-glucose:dolichyl phosphate glucosyltransferase. This enzyme participates in n-glycan biosynthesis.


  • Behrens NH, Leloir LF (1970). "Dolichol monophosphate glucose: an intermediate in glucose transfer in liver". Proc. Natl. Acad. Sci. U.S.A. 66 (1): 153–9. doi:10.1073/pnas.66.1.153. PMC 286101. PMID 5273893.
  • Herscovics A, Bugge B, Jeanloz RW (1977). "Glucosyltransferase activity in calf pancreas microsomes. Formation of dolichyl D[14C]glucosyl phosphate and 14C-labeled lipid-linked oligosaccharides from UDP-D-[14C]glucose". J. Biol. Chem. 252 (7): 2271–7. PMID 849929.
  • Villemez CL, Carlo PL (1979). "Properties of a soluble polyprenyl phosphate: UDP-D-glucose glucosyltransferase". J. Biol. Chem. 254 (11): 4814–9. PMID 438216.