He has been dating former 90210 star AnnaLynne McCord since 2011. In 2014 the couple announced an amicable split, but rekindled their romance a year later. McCord told People Magazine she came back into his life as a friend when the actor was diagnosed with skin cancer, but the relationship soon turned romantic again.
On June 1, 2016, Purcell suffered severe injuries on set in Morocco, after a misplaced iron bar used as a Prison Break season 5 set piece had fallen onto his head. The actor was immediately airlifted from Marrakesh to Casablanca, where he received emergency treatment for nasal fractures and various other injuries. As of June 7, Purcell is recovering, and the filming schedule has been adjusted to minimise disruption.