Don Craig Wiley

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Don Craig Wiley
Born (1944-10-21)October 21, 1944
Died November 1, 2001(2001-11-01) (aged 57)
Alma mater Harvard University
Doctoral students Michael Eisen[1][2][3]
Notable awards
Spouse Katrin Valgeirsdottir[4]

Don Craig Wiley (October 21, 1944 – November 2001) was an American structural biologist.[4][5][6][7][8]

Education[edit]

Wiley received his doctoral degree in biophysics in 1971 from Harvard University where he worked under direction of subsequent 1976 chemistry Nobel Prize winner William N. Lipscomb, Jr.[9] There, Wiley did early work on the structure of aspartate carbamoyltransferase, the largest molecular structure determined at that time.[10] Noteworthy in this effort is that Wiley managed to grow crystals of aspartate carbamoyltransferase suitable for doing its x-ray structure, a particularly difficult task in the case of this molecular complex.

Career and research[edit]

Wiley was world-renowned for finding new ways to help the human immune system battle such viral scourges as smallpox, influenza, AIDS,[11] Ebola, and herpes simplex.[12][13][14][15][16][17][18][19][20][21][22][23]

Famous quote: "I'm sorry, but I just don't understand anything in biology unless I know what it looks like."[citation needed]

Awards and honors[edit]

In 1990, he was awarded Louisa Gross Horwitz Prize from Columbia University. His research was honored with the 1993 Cancer Research Institute William B. Coley Award. Harvard called Wiley "one of the most influential biologists of his generation." In 1999, Wiley and another Harvard professor, Jack L. Strominger, won the Japan Prize for their discoveries of how the immune system protects humans from infections.[24]

Personal life[edit]

Wiley owned a British racing green-colored Aston Martin.[citation needed]

Don Wiley disappeared on November 15, 2001; his body was found in the Mississippi River a month later and his death was ruled to be an accident.[25][26][27]

References[edit]

  1. ^ Eisen, Michael Bruce (1996). Structural Studies of Influenza A Virus Proteins (PhD thesis). Harvard University. OCLC 48938206. 
  2. ^ Eisen, M. B.; Sabesan, S; Skehel, J. J.; Wiley, D. C. (1997). "Binding of the influenza a virus to cell-surface receptors: Structures of five hemagglutinin-sialyloligosaccharide complexes determined by X-ray crystallography". Virology 232 (1): 19–31. doi:10.1006/viro.1997.8526. PMID 9185585. 
  3. ^ Eisen, M. B.; Wiley, D. C.; Karplus, M; Hubbard, R. E. (1994). "HOOK: A program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site". Proteins: Structure, Function, and Genetics 19 (3): 199–221. doi:10.1002/prot.340190305. PMID 7937734. 
  4. ^ a b Ploegh, H. L. (2002). "Obituary: Don Craig Wiley (1944-2001)". Nature 415 (6871): 492. doi:10.1038/415492a. PMID 11823846. 
  5. ^ Strominger, J. L. (2002). "Don Craig Wiley (1944-2001): A reminiscence". Nature Immunology 3 (2): 103–4. doi:10.1038/ni0202-103. PMID 11812980. 
  6. ^ "Don C. Wiley (1944 - 2001) Memorial website of the Wiley laboratory". Harvard University. Archived from the original on 2014-08-10. 
  7. ^ Don Craig Wiley's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  8. ^ Lechler, R. (2002). "Don Craig Wiley (1944-2001)". American Journal of Transplantation 2 (5): 480. doi:10.1034/j.1600-6143.2002.20515.x. 
  9. ^ Harvard Gazette: Biologist Don C. Wiley, 1944-2001
  10. ^ Sondra, Schlesinger (1999). "Oral history: Don Wiley". Viruses: From structure to biology. American Society for Virology. Retrieved 2013-11-15. 
  11. ^ Weissenhorn, W; Dessen, A; Harrison, S. C.; Skehel, J. J.; Wiley, D. C. (1997). "Atomic structure of the ectodomain from HIV-1 gp41". Nature 387 (6631): 426–30. doi:10.1038/387426a0. PMID 9163431. 
  12. ^ Steitz, T. A.; Wiley, D. C.; Lipscomb, W. N. (1967). "The structure of aspartate transcarbamylase, I. A molecular twofold axis in the complex with cytidine triphosphate". Proceedings of the National Academy of Sciences of the United States of America 58 (5): 1859–61. PMC 223875. PMID 5237487. 
  13. ^ Wiley, D. N. C.; Lipscomb, W. N. (1968). "Crystallographic Determination of Symmetry of Aspartate Transcarbamylase". Nature 218 (5147): 1119. doi:10.1038/2181119a0. 
  14. ^ Warren, S. G.; Edwards, B. F.; Evans, D. R.; Wiley, D. C.; Lipscomb, W. N. (1973). "Aspartate transcarbamoylase from Escherichia coli: Electron density at 5.5 a resolution". Proceedings of the National Academy of Sciences of the United States of America 70 (4): 1117–21. PMC 433438. PMID 4577792. 
  15. ^ Honzatko, R. B.; Crawford, J. L.; Monaco, H. L.; Ladner, J. E.; Ewards, B. F.; Evans, D. R.; Warren, S. G.; Wiley, D. C.; Ladner, R. C.; Lipscomb, W. N. (1982). "Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli". Journal of Molecular Biology 160 (2): 219–263. doi:10.1016/0022-2836(82)90175-9. PMID 6757446. 
  16. ^ Edwards, B. F.; Evans, D. R.; Warren, S. G.; Monaco, H. L.; Landfear, S. M.; Eisele, G; Crawford, J. L.; Wiley, D. C.; Lipscomb, W. N. (1974). "Complex of aspartate carbamoyltransferase from Escherichia coli with its allosteric inhibitor, cytidine triphosphate: Electron density at 5.9-angstroms resolution". Proceedings of the National Academy of Sciences of the United States of America 71 (11): 4437–41. PMC 433901. PMID 4612518. 
  17. ^ Lipscomb, W. N.; Evans, D. R.; Edwards, B. F.; Warren, S. G.; Pastra-Landis, S; Wiley, D. C. (1974). "Three-dimensional structures at 5.5 a resolution and regulatory processes in aspartate transcarbamylase from E. Coli". Journal of Supramolecular Structure 2 (2-4): 82–98. doi:10.1002/jss.400020203. PMID 4612257. 
  18. ^ Wiley, D. C.; Evans, D. R.; Warren, S. G.; McMurray, C. H.; Edwards, B. F. P.; Franks, W. A.; Lipscomb, W. N. (1972). "The 5.5 a Resolution Structure of the Regulatory Enzyme, Aspartate Transcarbamylase". Cold Spring Harbor Symposia on Quantitative Biology 36: 285. doi:10.1101/SQB.1972.036.01.038. 
  19. ^ Evans, D. R.; Warren, S. G.; Edwards, B. F.; McMurray, C. H.; Bethge, P. H.; Wiley, D. C.; Lipscomb, W. N. (1973). "Aqueous central cavity in aspartate transcarbamylase from Escherichia coli". Science (New York, N.Y.) 179 (4074): 683–5. PMID 4567940. 
  20. ^ Bjorkman, P. J.; Saper, M. A.; Samraoui, B; Bennett, W. S.; Strominger, J. L.; Wiley, D. C. (1987). "Structure of the human class I histocompatibility antigen, HLA-A2". Nature 329 (6139): 506–12. doi:10.1038/329506a0. PMID 3309677. 
  21. ^ Brown, J. H.; Jardetzky, T. S.; Gorga, J. C.; Stern, L. J.; Urban, R. G.; Strominger, J. L.; Wiley, D. C. (1993). "Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1". Nature 364 (6432): 33–9. doi:10.1038/364033a0. PMID 8316295. 
  22. ^ Wilson, I. A.; Skehel, J. J.; Wiley, D. C. (1981). "Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution". Nature 289 (5796): 366. doi:10.1038/289366a0. 
  23. ^ Skehel, J. J.; Wiley, D. C. (2000). "Receptor Binding and Membrane Fusion in virus entry: The Influenza Hemagglutinin". Annual Review of Biochemistry 69: 531. doi:10.1146/annurev.biochem.69.1.531. 
  24. ^ "Authorities Search For Missing Harvard Virus Specialist". Fox News. 24 November 2001. 
  25. ^ "Professor Don C. Wiley, 1944-2001". Office of news and public affairs. Harvard University. 15 January 2002. Retrieved 15 November 2013. 
  26. ^ "Harvard Biologist's Death Ruled Accidental". The New York Times. 15 January 2002. Retrieved 15 November 2013. 
  27. ^ "Obituary: Professor Don C. Wiley, 1944-2001". Office of news and public affairs. Harvard University. 21 December 2001. Retrieved 15 November 2013.