Drysdale was also a good hitter for a pitcher. In 14 seasons, he had 218 hits, including 29 home runs, and was occasionally used as a pinch-hitter, once even during the World Series.
The ball thrown for the final out of Drysdale's consecutive scoreless innings streak in 1968.
In 1962, Drysdale won 25 games and the Cy Young Award. In 1963, he struck out 251 batters and won Game 3 of the World Series at Los Angeles' Dodger Stadium over the Yankees, 1–0. In 1965, he was the Dodgers' only .300 hitter and tied his own National League record for pitchers with seven home runs. That year, he also won 23 games and helped the Dodgers to their third World Championship in Los Angeles. In 1968, he set Major League records with six consecutive shutouts and 582⁄3 consecutive scoreless innings; the latter record was broken by fellow Dodger Orel Hershiser 20 years later. He ended his career with 209 wins, 2,486 strikeouts, 167 complete games and 49 shutouts. He was inducted into the Baseball Hall of Fame in 1984, and had his number 53 retired at Dodger Stadium on July 1, 1984. He was also the last player on the Dodgers who had played for Brooklyn.
He won three NL Player of the Month awards: June 1959 (6-0 record, 1.71 earned run average, 51 strikeouts), July 1960 (6-0 record, 2.00 earned run average, 48 strikeouts), and May 1968 (5-1 record, 0.53 earned run average, 45 strikeouts, with 5 consecutive shutouts to begin his scoreless inning streak, which was carried into June).
In 1965, Sandy Koufax declined to pitch the first game of the World Series because it was on Yom Kippur, a Jewish holy day. Drysdale pitched for the Dodgers instead of Koufax, and gave up seven runs in 2 2/3 innings. When Walter Alston, the manager, came to the mound to remove him from the game, Drysdale said, "I bet right now you wish I was Jewish, too." The Dodgers lost to the Minnesota Twins, 8-2.
Drysdale and Koufax took part in a famous salary holdout together in the spring of 1966, with both finally signing contracts just before the season opened. Those contracts made them the first pitchers to earn more than $100,000 a year. This holdout was the beginning of collective bargaining in baseball.
While broadcasting for the White Sox, Drysdale generated some controversy while covering a heated argument between an umpire and Sox manager Tony LaRussa. LaRussa pulled up the third base bag and hurled it into the outfield, to the approval of the Comiskey Park crowd, and ensuring his ejection. Drysdale remarked, "Go get 'em, Dago!"
For the Sox, Drysdale broadcast Tom Seaver's 300th victory, against the host New York Yankees in 1985. His post-game interview with Seaver was carried live by both the Sox' network and the Yankees' longtime flagship television station WPIX.
Drysdale hosted a nationally syndicated radio show called Radio Baseball Cards. 162 episodes were produced with stories and anecdotes told by current and former Major League Baseball players. The highlight of the series were numerous episodes dedicated to the memory and impact of Jackie Robinson as told by teammates, opponents and admirers. Radio Baseball Cards aired on 38 stations, including WNBC New York, KSFO San Francisco and WEEI Boston, as a pre-game show. A collector's edition of the program was re-released in 2007 as a podcast.
Drysdale conducted all of the National League player interviews for the Baseball Talk series in 1988 (Joe Torre did the same for the American League).
On September 28, 1988, fellow Dodger Orel Hershiser surpassed Drysdale when Hershiser finished the season with a record 59 consecutive scoreless innings pitched. In his final start of the year, Hershiser needed to pitch 10 shutout innings to set the mark – meaning not only that he would have to prevent the San Diego Padres from scoring, but that his own team would also need to fail to score in order to ensure extra innings. The Dodgers' anemic offense obliged, and Hershiser pitched the first 10 innings of a scoreless tie, with the Padres eventually prevailing 2–1 in 16 innings. Hershiser almost did not pitch in the 10th inning, in deference to Drysdale, but was convinced to take the mound and try to break the record. When Hershiser broke Drysdale's record, Drysdale went to hug him, and said, "Oh, I'll tell ya, congratulations... And at least you kept it in the family."
Well, the crowd is on its feet and if there was ever a preface to 'Casey at the Bat' it would have to be the ninth inning. Two out. The tying run aboard, the winning run at the plate, and Kirk Gibson, standing at the plate. Eckersley working out of the stretch, here's the three-two pitch...and a drive hit to right field (losing voice) WAY BACK! THIS BALL IS GONE! (After 2 minutes of crowd noise) This crowd will not stop! They can't believe the ending! And this time, Mighty Casey did NOT strike out!!!!
Drysdale married Ginger Dubberly in 1958, with whom he had a daughter, Kelly. They divorced in 1982. On November 1, 1986, he married basketball player Ann Meyers, who took the name Ann Meyers-Drysdale. Drysdale and Meyers had three children together: Don Junior ("DJ") (son), Darren (son), and Drew (daughter). In 1990, Drysdale published his autobiography, Once a Bum, Always a Dodger.
Drysdale's broadcasting colleague Vin Scully, who was instructed not to say anything on the air until Drysdale's family was notified, announced the news of his death by saying, "Never have I been asked to make an announcement that hurts me as much as this one. And I say it to you as best I can with a broken heart." Fellow broadcaster Ross Porter told his radio audience, "I just don't believe it, folks." Drysdale was replaced by Rick Monday in the broadcast booth.
Drysdale was a popular guest star in several television programs:
The Beverly Hillbillies: The Clampetts & The Dodgers. Don Drysdale & Leo Durocher are guest stars in this episode when Jed & Jethro play golf with the Dodgers and Leo Durocher finds out Jed & Jethro are good baseball prospects. April 10, 1963.
The Greatest American Hero (episode "The Two Hundred Mile an Hour Fastball", which was first broadcast on November 4, 1981 as a broadcaster for the California Stars.
The Brady Bunch episode "The Dropout", which was first broadcast on September 25, 1970.
The Donna Reed Show episodes "The Man in the Mask," first broadcast in 1962; "All Those Dreams," first broadcast in 1963; and "Play Ball" and "My Son the Catcher," both first broadcast in 1964. In all four episodes Drysdale played himself, and in "All Those Dreams" he appeared with first wife, Ginger, and daughter Kelly.
The Rifleman episode "Skull", which was first broadcast on January 1, 1962.
The Millionaire episode "Millionaire Larry Maxwell", which was first broadcast on March 1, 1960.
With his first wife, Ginger, on February 26, 1959 edition of You Bet Your Life with host Groucho Marx. The episode was released on the 2006 DVD "Groucho Marx: You Bet Your Life – 14 Classic Episodes".
In 1959, Drysdale appeared as a mystery challenger on the TV panel show To Tell the Truth.
The Flying Nun episode "The Big Game", 1st episode of the 3rd season, aired September 17, 1969.