Donitriptan ( INN) (code name F-11356) is a triptan drug which was investigated as an antimigraine agent but ultimately was never marketed. It acts as a high-  affinity, high- efficacy/near- full agonist of the 5-HT (pK 1B i = 9.4–10.1; IA = 94%) and 5-HT (pK 1D receptors i = 9.3–10.2; IA = 97%), and is among the most potent of the triptan series of drugs.   Donitriptan was being developed in  France by bioMérieux- Pierre Fabre and made it to phase II clinical trials in Europe before development was discontinued.  
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