The song "Negasonic Teenage Warhead" became the band's first hit single, after having appeared the previous year in different form in the American movie S.F.W.. Other tracks, such as the title track and "Dead Christmas" however, received little or no airplay, resulting in sales of the album being only slightly better than their previous album, Superjudge. The album did reach #51 on the UK Charts and #30 in the German Charts.
A shorter version of the song "Look to Your Orb for the Warning" appears in the soundtrack of the film The Matrix.
A music video was made for the song "Negasonic Teenage Warhead".
In 2011, Monster Magnet revisited the album when they embarked on "Dopes To Infinity 2011: The European Tour", performing the album live in its entirety at several European locations.
During the early days of MTV2 (1998), in between music videos, a conversation in the woods of two stoner types was shown whereby one of the two mentions that Dopes to Infinity was one of the best albums of all time.
The track "Look to Your Orb for the Warning" was featured on The Matrix soundtrack.
The main guitar riff to the song Dopes To Infinity was lifted from the 1971 song "Woman Tamer" by the proto-heavy metal band Sir Lord Baltimore