Double knockout may refer to:
- Gene knockout a genetic technique in which two of an organism's genes is made inoperative.
- A rare fight-ending occurrence in several full-contact combat sports, such as boxing, and other sports involving striking, as well as in fighting video games, when both fighters knock each other out at the same time and are both unable to get back up before the count is over, such as the 1912 World Lightweight Title boxing match between Mexican Joe Rivers and Ad Wolgast.
disambiguation page lists articles associated with the title Double knockout.
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