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- Charles Drechsler (1892–1986), American mycologist
- Dave Drechsler (born 1960), former guard in the National Football League
- Debbie Drechsler (born 1953), American illustrator and comic book creator
- Hanno Drechsler (1931–2003), German political scientist
- Heike Drechsler (born 1964), German track and field athlete
- Margot Dreschel (1908–1945), SS-Aufseherin at many Nazi German concentration camps.
- Otto-Heinrich Drechsler (1895–1945), German dentist, mayor of Lübeck, General Commissioner of Latvia for the Nazi occupation regime
- Paul Drechsler, British businessman.
- Werner Drechsler (1923–1944), German U-boat crewman
- Wolfgang Drechsler (born 1963), member of the Order of Merit of the Federal Republic of Germany