Dromotropic derives from the Greek word "dromos", meaning running, a course, a race. A dromotropic agent is one which affects the conduction speed in the AV node, and subsequently the rate of electrical impulses in the heart.
Non-dihydropyridine calcium channel blockers such as verapamil block the slow inward calcium current in cardiac tissues, thereby having a negatively dromotropic, chronotropic and inotropic effect. This (and other) pharmacological effect makes these drugs useful in the treatment of angina pectoris. Conversely, they can lead to symptomatic disturbances in cardiac conduction and bradyarrhythmias, and may aggravate left ventricular failure.
- Furukawa, Y.; Wallick, D. W.; Martin, P. J.; Levy, M. N. (1 May 1990). "Chronotropic and dromotropic responses to stimulation of intracardiac sympathetic nerves to sinoatrial or atrioventricular nodal region in anesthetized dogs". Circulation Research 66 (5): 1391–1399. doi:10.1161/01.RES.66.5.1391. PMID 2335032.
- Dromotropic at eMedicine Dictionary
- eTG complete
- AccessMedicine - Harrison's Internal Medicine: Stable Angina Pectoris[dead link]