Drostanolone propionate

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Drostanolone propionate.svg
Systematic (IUPAC) name
Clinical data
  • X
Legal status
Routes of
Intramuscular injection or transdermal cream
Pharmacokinetic data
Bioavailability Oral 0-2%, Intramuscular 100%
Protein binding highly
Metabolism hepatic
Biological half-life 2-3 Days
Excretion renal
CAS Number 58-19-5 YesY
ATC code A14
PubChem CID 224004
DrugBank DB00858 YesY
ChemSpider 194604 YesY
ChEBI CHEBI:31523 YesY
Chemical data
Formula C23H36O3
Molar mass 360.53 g/mol

Drostanolone propionate (trade name Masteron) is an anabolic/androgenic steroid which is the propionate ester of drostanolone. It is known to be androgenic and anabolic.[citation needed] It is incapable of aromatization and has similar properties to dihydrotestosterone.[citation needed] It has been successfully used as a breast cancer drug, but because of the high risk of virilization, safer options are prescribed.[1]

Use in sports[edit]

Drostanolone is beneficial to runners and athletes who must remain in a certain weight class.[citation needed]

It has gained popularity in the bodybuilding community as a diuretic and muscle defining drug. Individuals interested in using the drostanolone propionate are those that are looking to add muscle hardness and density to their physiques, nearly always for the purpose of bodybuilding competitions.[citation needed]

Drostanolone propionate can increase muscle hardness and density, giving an individual a more complete appearance when competing on stage.[citation needed] However, an already rather low body-fat level is needed for it to take full effect.[citation needed] Drostanolone propionate can promote increased strength while keeping body fat the same or even lowering it, and can help to prevent muscle loss while dieting.[citation needed] This can also allow strength athletes or those athletes in sports which have weight classes to increase performance without the risk of being raised into a higher weight class or add mass that may hinder performance.[citation needed]


  1. ^ Chowdhury MS, Banks AJ, Bond WH, Jones WG, Ward HW (1976). "A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin) in the treatment of breast carcinoma". Clin Oncol 2 (3): 203–6. PMID 103698.