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Drotaverine ball-and-stick.png
Clinical data
Trade names No-Spa, Doverin
AHFS/Drugs.com International Drug Names
Routes of
Oral, intravenous, intramuscular
ATC code
Legal status
Legal status
  • OTC (tablets), ℞-only (solution for injection) (RU)[1]
Pharmacokinetic data
Bioavailability Highly variable (~65%), peak at 45–60 min
Protein binding 95–98%
Metabolism Hepatic
Biological half-life 7–16 hours
Excretion >50% in urine and ~30% in bile[1]
CAS Number
PubChem CID
ECHA InfoCard 100.130.526
Chemical and physical data
Formula C24H31NO4
Molar mass 397.507 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth.[2]:283

It is structurally related to papaverine, is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.[3]

It is available in Asian and Eastern European countries under several brand names.[4]

An article from 2013 described the effects from overdose (in a 19-year-old woman) as including vomiting, seizures and fatal cardiac toxicity.[5]

In 2016, the young Russian chess player Ivan Bukavshin died of a massive overdose (or poisoning) of the drug, which was originally thought to be a stroke.[6] his doses was 17 mg/kg in the blood stream.


In Israel the product is known under the brand name "No-Spa" by the general public[7] which did not receive a permit to be distributed by the health ministry,[8] However due to high demand local medical counterfeiters had managed to smuggle No-Spa tablets during the years.[8]

In 2008 the Israeli health organization warned consumers from counterfeit No-SPA pilles after a smuggler had been arrested at the Ben Gurion Airport with several thousand pills.[9][10]

In 2011 Israeli patent and trade mark office declined the use of the No-SPA.[7]


  1. ^ a b "Инструкция по применению препарата Но-шпа® // No-Spa® (tablets) Full Prescribing Information". National Register of Drugs (in Russian). Chinoin Pharmaceutical and Chemical Works. pp. 3–8. 
  2. ^ Padubidri V and Anand E. Title Textbook of Obstetrics. BI Publications Pvt Ltd, 2006 ISBN 9788172252236
  3. ^ "The DrugBank database: Drotaverine". DrugBank Version 4.1. The Metabolomics Innovation Centre. Retrieved 9 August 2014. 
  4. ^ Drotaverine - Drugs.com Drugs.com international listings for drotaverine Page accessed June 28, 2015
  5. ^ Drotaverine overdose (case report) Reactions Weekly, Volume 1481 (1), page 17.
  6. ^ Silence, lack of will, indifference (Russian, Chess-News)
  7. ^ a b NO-SPA (also pronounced as No-SHPA) trade mark registration decision 202248, Israeli patent and trade mark office,11 July 2007
  8. ^ a b Health Ministry: Fake drug had been smuggled NRG, 11 March 2009
  9. ^ Health Ministry: Counterfeit NO-SPA pills had been smuggled and are considered a health risk, Globes
  10. ^ https://www.inn.co.il/News/Flash.aspx/209104