Drug diversion is a medical and legal concept involving the transfer of any legally prescribed controlled substance from the individual for whom it was prescribed to another person for any illicit use. The definition varies slightly among different jurisdictions, but the transfer of a controlled substance alone usually does not constitute a diversion, since certain controlled substances that are prescribed to a child are intended to be administered by an adult, as directed by a medical professional. The term comes from the "diverting" of the drugs from their original licit medical purpose. In some jurisdictions, drug diversion programs are available to first time offenders of diversion drug laws, which "divert" offenders from the criminal justice system to a program of education and rehabilitation.
Commonly diverted drugs
Controlled prescription drug classes which are commonly diverted include:
- Benzodiazepines – including diazepam, temazepam, clonazepam, and alprazolam – prescription anxiolytics and sedatives
- Opioids – including morphine, hydrocodone, oxycodone and codeine – prescription pain medications
- Stimulants – amphetamine, methylphenidate, and modafinil – prescribed to treat ADHD and narcolepsy
- Z-drugs – including zolpidem (Ambien), Eszopiclone (Lunesta) – prescription sleep medications
According to the United States Department of Justice, "Most pharmaceuticals abused in the United States are diverted by doctor shopping, forged prescriptions, theft and, increasingly, via the Internet."  To reduce the occurrence of pharmaceutical diversion by doctor shopping and prescription fraud, almost all states have established prescription monitoring programs (PMPs) that facilitate the collection, analysis, and reporting of information regarding pharmaceutical drug prescriptions.
Registration of drug suppliers
21 U.S.C. § 823 of the Controlled Substances Act provides for registration of manufacturers and distributors of controlled substances. The criteria for registering manufacturers of Schedule I and II drugs are particularly strict and call for "limiting the importation and bulk manufacture of such controlled substances to a number of establishments which can produce an adequate and uninterrupted supply of these substances under adequately competitive conditions for legitimate medical, scientific, research, and industrial purposes." The Attorney General must make a positive determination that the registration would be "consistent with the public interest."
For manufacturers of other drugs, and for drug distributors, the regulations are substantially less strict: "The Attorney General shall register an applicant… unless he determines that the issuance of such registration is inconsistent with the public interest." The criteria for both manufacture and distribution is somewhat biased in favor of established industries, favoring "past experience" and a record of compliance with drug laws The Controlled Substances Act also provides for the registration of medical practitioners (i.e., physicians, dentists, veterinarians, etc.), pharmacies and hospitals that prescribe, administer, or dispense controlled substances directly to patients, as well as individuals conducting approved research involving controlled substances. This category also includes narcotic treatment programs that administer and dispense primarily Methadone for narcotic addiction treatment.[medical citation needed]
This activity can occur in many venues;
occurs in a variety of ways, by all segments of our population, in all neighborhoods, and in all workplaces. Its abuse is often overlooked by the thinking that if a doctor prescribes the drug, and a pharmacist dispenses the medication, it can’t be abused. Understanding that the top prescription drugs of abuse are every bit as addictive, abused, and valuable as illicit drugs, is sometimes difficult to comprehend.
The Cincinnati Post has reported on its frequency. John Burke, a leading expert on the issue, was quoted as saying, "Pharmaceutical diversion is kind of funny because it's going on in every community, but it appears not to exist unless you go after it purposely," 
DEA investigation into Oxycodone diversion
According to the US Justice Department, in 2011 CVS pharmacies in Sanford, Florida, ordered enough painkillers to supply a population eight times its size. Sanford has a population of 53,000 but the supply would support 400,000. According to the Drug Enforcement Administration, in 2010 a single CVS pharmacy in Sanford ordered 1.8 million Oxycodone pills, an average of 137,994 pills a month. Other pharmacy customers in Florida averaged 5,364 oxycodone pills a month. DEA investigators serving a warrant to a CVS pharmacy in Sanford on Oct. 18 2011 noted that "approximately every third car that came through the drive-thru lane had prescriptions for oxycodone or hydrocodone." According to the DEA, a pharmacist at that location stated to investigators that "her customers often requested certain brands of oxycodone using street slang," an indicator that the drugs were being diverted and not used for legitimate pain management. In response, CVS in a statement issued February 17 in response to opioid trafficking questions from USA Today said the company is committed to working with the DEA and had taken "significant actions to ensure appropriate dispensing of painkillers in Florida." 
- Berge KH, Dillon KR, Sikkink KM, Taylor TK, Lanier WL (2012). "Diversion of drugs within health care facilities, a multiple-victim crime: patterns of diversion, scope, consequences, detection, and prevention". Mayo Clin. Proc. 87 (7): 674–82. doi:10.1016/j.mayocp.2012.03.013. PMC 3538481. PMID 22766087.
- "Drug Diversion Defined: A Patient Safety Threat | Safe Healthcare | Blogs | CDC". blogs.cdc.gov. Retrieved 2015-07-15.
- McCabe SE, Teter CJ, Boyd CJ (2006). "Medical use, illicit use, and diversion of abusable prescription drugs". J Am Coll Health 54 (5): 269–78. doi:10.3200/JACH.54.5.269-278. PMC 1876754. PMID 16539219.
- US Department of Justice web site
- "Prescription Drug Monitoring Programs (PDMPs)". www.cdc.gov. Retrieved 2016-05-04.
- Whitehead, Shelly (2005-01-18). "Police target prescription abuse". The Cincinnati Post (E. W. Scripps Company). Archived from the original on 2005-03-12.
- Schoenberg, Tom (2012-02-29). "Cardinal Health Blocked From Shipping Painkiller in Florida". Bloomberg.
- "Most Popular E-mail Newsletter". USA Today. 2012-02-27.
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