Using drug repositioning, pharmaceutical companies have achieved a number of successes; for example, Pfizer's Viagra for erectile dysfunction and Celgene's thalidomide for leprosy and multiple myeloma. For companies dedicated to drug repositioning as a discovery strategy the approaches include in silico biology and in vivo  /in vitro experimentation to assess a compound and develop and confirm hypotheses concerning its usage for new indications.
From reference 1, published 2014: "Drug repurposing is the use of an approved drug or a drug under development for a different indication than that for which it was originally developed. Drug repositioning has recently been used to describe the novel use of a drug that was previously discontinued for development. (For the purposes of this workshop summary) drug repurposing and repositioning are used interchangeably."
- Institute of Medicine (2014). Drug Repurposing and Repositioning: Workshop Summary. National Academies Press. ISBN 978-0-309-30204-3.
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- Pritchard JL, O'Mara TA, Glubb DM (December 2017). "Enhancing the promise of drug repositioning through genetics". Frontiers in Pharmacology. 8: 896. PMID 29270124.