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For a while, the Beylik of Dulkadiroğulları had an influence extending from Kırşehir to Mosul, but with the rise of the Ottomans, they became a buffer state between the Ottomans and the Mameluks of Egypt. They became part of the Ottoman Empire in early 16th century. Until the mid-19th century, the region centered on the town of Elbistan in Kahramanmaraş Province of Turkey was often referred to as Dulkadiroğulları (or Zulkadriyye ) State in Ottoman documents.
The Dulkadir dynasty also gave many brides to the Ottoman dynasty. Emine Hatun, the daughter of Nasreddin Mehmed Bey, the fifth ruler of Dulkadiroğulları State, was Mehmed I's third consort, and thus the mother of Ottoman SultanMurad II. Their marriage served as an alliance between the Ottomans and this buffer state. Their son Murad II is the ancestor of all succeeding Sultans. Similarly, Mükrime Hatun, the daughter of Süleyman Bey, the sixth ruler of Dulkadiroğulları State, was the third wife of Ottoman SultanMehmed II. Moreover, Ayşe Hatun, the daughter of Alaüddevle Bozkurt, the eleventh ruler of the Dulkadir State, was the wife of Ottoman Sultan Bayezid II, and consequently the stepmother of Selim I.