Duodenal cytochrome B

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cytochrome b reductase 1
Symbol CYBRD1
Alt. symbols DCYTB
Entrez 79901
HUGO 20797
OMIM 605745
RefSeq NM_024843
UniProt Q53TN4
Other data
Locus Chr. 2 q31

Duodenal cytochrome B (Dcytb) has been identified as the reductase enzyme which catalyzes the reduction of Fe3+ to Fe2+ in the process of iron absorption in the duodenum of mammals.[1] According to research carried out, it appears that Dcytb upregulation is controlled by a number of independent stimulators or inhibitors of iron absorption. Furthermore, Dcytb has also been shown to exist in other tissues besides the apical region of the duodenum; and as such, it is believed to play a major role in iron metabolism in tissues.


  1. ^ Latunde-Dada GO, Van der Westhuizen J, Vulpe CD, et al. (2002). "Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism". Blood Cells Mol. Dis. 29 (3): 356–60. doi:10.1006/bcmd.2002.0574. PMID 12547225. 

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